Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr
文献类型：期刊论文
| 作者 | Du Li-Bo; Wang Guang-Qing; Han Lu; Jia Hong-Ying; Tian Qiu; Liu Yang |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2009-10-10 |
| 卷号 | 30期号:10页码:2009-2011 |
| 关键词 | Spin Trapping Bioconjugate Superoxide Anion Nitrone Free Radical |
| ISSN号 | 0251-0790 |
| 英文摘要 | L-Tyr-EMPO, a new EMPO analogue bearing an L-tyrosine methyl ether group, was first synthesized by acylation. Various radicals, including O(2)(-center dot), (center dot)OH, (center dot)OR, and (center dot)R, have been efficiently detected and characterized via L-Tyr-EMPO. The half-life of the L-Tyr-EMPO superoxide adduct was estimated to be ca. 6.5 min. More importantly, the present study demonstrated a new synthetic strategy for covalent conjugation between cyclic-nitrone and amino group in peptides or proteins, by which the site-specifically spin trapping can be performed via antibody linked nitrone in the near future. Furthermore, with the help of the covalent link, the targeting for the areas of interest in which the monitored radical species was sitespecially generated. |
| 语种 | 英语 |
| WOS记录号 | WOS:000272151100019 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67911]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu Yang |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du Li-Bo,Wang Guang-Qing,Han Lu,et al. Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(10):2009-2011. |
| APA | Du Li-Bo,Wang Guang-Qing,Han Lu,Jia Hong-Ying,Tian Qiu,&Liu Yang.(2009).Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(10),2009-2011. |
| MLA | Du Li-Bo,et al."Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.10(2009):2009-2011. |
入库方式： OAI收割
来源：化学研究所
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