Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers
文献类型：期刊论文
| 作者 | Shi, Quan1,2; Huang, Yubin1; Chen, Xuesi1; Wu, Meng3; Sun, Jing1,2; Jing, Xiabin1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 30期号:28页码:5077-5085 |
| 关键词 | Hemoglobin Artificial Oxygen Carrier Red Blood Cells Micelles |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2009.05.082 |
| 英文摘要 | An artificial oxygen carrier is constructed by conjugating hemoglobin molecules to biodegradable micelles. Firstly a series of triblock copolymers (PEG-PMPC-PLA) in which the middle block contains pendant propargyl groups were synthesized and characterized. After the amphiphilic copolymer was self-assembled into core-shell micelles in aqueous solution, azidized hemoglobin molecules protected by carbon monoxide (CO) were conjugated to the micelles via click reaction between the propargyl and azido groups. The conjugation causes an increase of the micelle's mean diameter. Maximum conjugation ratio is 250 wt% in the hemoglobin-conjugated micelles (HCMs). Oxygen-binding ability of the HCMs was demonstrated by converting the CO-binding state of the HCMs into O(2)-binding state. (C) 2009 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000269459900025 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67917]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Jilin Univ, Dept Mat Sci & Engn, Changchun 130025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Quan,Huang, Yubin,Chen, Xuesi,et al. Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers[J]. BIOMATERIALS,2009,30(28):5077-5085. |
| APA | Shi, Quan,Huang, Yubin,Chen, Xuesi,Wu, Meng,Sun, Jing,&Jing, Xiabin.(2009).Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers.BIOMATERIALS,30(28),5077-5085. |
| MLA | Shi, Quan,et al."Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers".BIOMATERIALS 30.28(2009):5077-5085. |
入库方式： OAI收割
来源：化学研究所
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