Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL
文献类型：期刊论文
| 作者 | Mao Jing1,2; Gan Zhi-Hua1 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 30期号:11页码:2291-2296 |
| 关键词 | Amphiphilic Graft Copolymer Poly(Ethylene Oxide) Poly(Epsilon-caprolactone) Self-assembly Drug Release |
| ISSN号 | 0251-0790 |
| 英文摘要 | Water-soluble diblock copolymers PEO-b-PGL with well controlled composition were synthesized by sequential anionic ring-opening copolymerization of ethylene oxide (EO) and glycidol (GL). epsilon-Caprolactone (CL) was further initiated by the pendant hydroxyl group of each GL unit in PEO-b-PGL copolymer to synthesize amphiphilic graft copolymers PEO-b-PGL-g-PCL with well defined grafting architecture. The self-assembly behavior of PEO-b-PGL-g-PCL graft copolymers was investigated with pyrene as a probe for the determination of critical micelle concentrations (cmc). Meanwhile, doxorubicin as a model drug was encapsulated into PEO-b-PGL-g-PCL micelles, and its release behavior controlled by diffusion and enzymatic degradation was studied. The influences of composition and grafting structure in PEO-b-PGL-g-PCL copolymers on self-assembly, drug loading and release were discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000272832200037 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67929]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gan Zhi-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao Jing,Gan Zhi-Hua. Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(11):2291-2296. |
| APA | Mao Jing,&Gan Zhi-Hua.(2009).Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(11),2291-2296. |
| MLA | Mao Jing,et al."Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.11(2009):2291-2296. |
入库方式： OAI收割
来源：化学研究所
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