Simulation Study of Protein-Mediated Vesicle Fusion
文献类型：期刊论文
| 作者 | Wu, Shaogui; Guo, Hongxia |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2009-01-22 |
| 卷号 | 113期号:3页码:589-591 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp808776z |
| 英文摘要 | A dissipative particle dynamics simulation method is used to probe the mechanism of protein-mediated membrane fusion. The coarse-grained models for proteins are designed based on the function of fusion proteins. Attractive forces have been introduced to produce a protein complex. The formation of protein complexes provides mechanical forces to bring membranes in proximity and trigger their merging. The whole fusion process is in good agreement with the scaffold hypothesis. Additionally, if self-defined interactions are also imposed on transmembrane segments (TMSs), their association will yield an unstable fusion pore, which can incorporate lipid and water to accomplish membrane fusion. It indicates the formation of a protein-lined pore will promote the stalk-pore transition and accelerate the fusion process. |
| 语种 | 英语 |
| WOS记录号 | WOS:000262522200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67943]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Guo, Hongxia |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci,Joint Lab Polymer Sci &, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Shaogui,Guo, Hongxia. Simulation Study of Protein-Mediated Vesicle Fusion[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2009,113(3):589-591. |
| APA | Wu, Shaogui,&Guo, Hongxia.(2009).Simulation Study of Protein-Mediated Vesicle Fusion.JOURNAL OF PHYSICAL CHEMISTRY B,113(3),589-591. |
| MLA | Wu, Shaogui,et al."Simulation Study of Protein-Mediated Vesicle Fusion".JOURNAL OF PHYSICAL CHEMISTRY B 113.3(2009):589-591. |
入库方式： OAI收割
来源：化学研究所
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