中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates

文献类型:期刊论文

作者Me, Zhigang1,2; Lu, Tiancheng1,2; Chen, Xuesi1; Zheng, Yonghui1; Jing, Xiabin1
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
出版日期2009
卷号88A期号:1页码:238-245
关键词Mpeg-plla Conjugate Antitumor
ISSN号1549-3296
DOI10.1002/jbm.a.31861
英文摘要Docetaxel (DX) is one of the most effective antineoplastic drugs. Its current clinical administration is limited because of its hydrophobicity and Serious side effects. A polymer/DX conjugate is designed and successfully prepared to solve these problems. It is monomethoxy-poly(ethylene glycol)-block-poly(L-lactide)/DX (MPEG-PLLA/DX) It was synthesized by reacting DX with carboxyl-terminated copolymer MPEG-PLLA, which was prepared by reacting succinic anhydride with hydroxyl-terminated copolymer monomethoxy-poly(ethylene glycol)-block-poly (L-lactide) (MPEG-PLLA). Its structure and molecular weight was confirmed by (1)H NMR and GPC. The MPEG-PLLA/DX micelles in aqueous solution were prepared Using a SO]vent displacement method and characterized by dynamic light scattering for size and size distribution, and by transmission electron microscopy for surface morphology. Its antitumor activity against HeLa cancer cells evaluated by MTT assay showed that it had a similar antitumor activity to Pure D at the same drug content. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Re 88A: 238-245,
语种英语
WOS记录号WOS:000261471900023
出版者WILEY-LISS
源URL[http://ir.iccas.ac.cn/handle/121111/68103]  
专题中国科学院化学研究所
通讯作者Jing, Xiabin
作者单位1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714
Me, Zhigang,Lu, Tiancheng,Chen, Xuesi,et al. Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2009,88A(1):238-245.
APA Me, Zhigang,Lu, Tiancheng,Chen, Xuesi,Zheng, Yonghui,&Jing, Xiabin.(2009).Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,88A(1),238-245.
MLA Me, Zhigang,et al."Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 88A.1(2009):238-245.

入库方式: OAI收割

来源:化学研究所

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