Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates
文献类型:期刊论文
作者 | Me, Zhigang1,2; Lu, Tiancheng1,2; Chen, Xuesi1; Zheng, Yonghui1; Jing, Xiabin1 |
刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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出版日期 | 2009 |
卷号 | 88A期号:1页码:238-245 |
关键词 | Mpeg-plla Conjugate Antitumor |
ISSN号 | 1549-3296 |
DOI | 10.1002/jbm.a.31861 |
英文摘要 | Docetaxel (DX) is one of the most effective antineoplastic drugs. Its current clinical administration is limited because of its hydrophobicity and Serious side effects. A polymer/DX conjugate is designed and successfully prepared to solve these problems. It is monomethoxy-poly(ethylene glycol)-block-poly(L-lactide)/DX (MPEG-PLLA/DX) It was synthesized by reacting DX with carboxyl-terminated copolymer MPEG-PLLA, which was prepared by reacting succinic anhydride with hydroxyl-terminated copolymer monomethoxy-poly(ethylene glycol)-block-poly (L-lactide) (MPEG-PLLA). Its structure and molecular weight was confirmed by (1)H NMR and GPC. The MPEG-PLLA/DX micelles in aqueous solution were prepared Using a SO]vent displacement method and characterized by dynamic light scattering for size and size distribution, and by transmission electron microscopy for surface morphology. Its antitumor activity against HeLa cancer cells evaluated by MTT assay showed that it had a similar antitumor activity to Pure D at the same drug content. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Re 88A: 238-245, |
语种 | 英语 |
WOS记录号 | WOS:000261471900023 |
出版者 | WILEY-LISS |
源URL | [http://ir.iccas.ac.cn/handle/121111/68103] ![]() |
专题 | 中国科学院化学研究所 |
通讯作者 | Jing, Xiabin |
作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Me, Zhigang,Lu, Tiancheng,Chen, Xuesi,et al. Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2009,88A(1):238-245. |
APA | Me, Zhigang,Lu, Tiancheng,Chen, Xuesi,Zheng, Yonghui,&Jing, Xiabin.(2009).Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,88A(1),238-245. |
MLA | Me, Zhigang,et al."Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 88A.1(2009):238-245. |
入库方式: OAI收割
来源:化学研究所
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