Triggered release of insulin from glucose-sensitive enzyme multilayer shells
文献类型：期刊论文
| 作者 | Qi, Wei; Yan, Xuehai; Fei, Jinbo; Wang, Anhe; Cui, Yue; Li, Junbai |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 30期号:14页码:2799-2806 |
| 关键词 | Glucose-sensitive Release Of Insulin Microcapsules Glucose Oxidase Catalase |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2009.01.027 |
| 英文摘要 | A glucose-sensitive multilayer shell, which was fabricated by the layer-by-layer (LbL) assembly method, can be used as a carrier for the encapsulation and controlled release of insulin. In the present report, glucose oxidase (GOD) and catalase (CAT) were assembled on insulin particles alternately via glutaraldehyde (GA) cross-linking. The resulting core-shell system has been proven to be glucose-sensitive. When the external glucose was introduced, the release ratio of insulin from the protein multilayer can be increased observably. This is likely attributed to the catalysis interaction of CAT/GOD shells to glucose, which leads to the production of H(+) and thus drops the pH of the microenvironment. Under the acidic conditions, on the one hand, a part of C=N bond formed from Schiff base reaction can be broken and thus increasing the permeability of the capsule wall. On the other hand, the Solubility of insulin can also be increased. The above factors may be the key control to increase the release of insulin from the multilayer. Therefore, such CAT/GOD multilayer may have a great potential as a glucose-sensitive release carrier for insulin, and may open the way for the further application of LbL capsules in the drug delivery and controlled release, etc. (C) 2009 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000264953900016 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68111]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS,Int Joint Lab, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Wei,Yan, Xuehai,Fei, Jinbo,et al. Triggered release of insulin from glucose-sensitive enzyme multilayer shells[J]. BIOMATERIALS,2009,30(14):2799-2806. |
| APA | Qi, Wei,Yan, Xuehai,Fei, Jinbo,Wang, Anhe,Cui, Yue,&Li, Junbai.(2009).Triggered release of insulin from glucose-sensitive enzyme multilayer shells.BIOMATERIALS,30(14),2799-2806. |
| MLA | Qi, Wei,et al."Triggered release of insulin from glucose-sensitive enzyme multilayer shells".BIOMATERIALS 30.14(2009):2799-2806. |
入库方式： OAI收割
来源：化学研究所
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