Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity
文献类型：期刊论文
| 作者 | Xu, Xiuling2; Chen, Xuesi; Wang, Zhanfeng3; Jing, Xiabin1 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 72期号:1页码:18-25 |
| ISSN号 | 0939-6411 |
| 关键词 | Emulsion-electrospinning Peg-pla Fibers Drug Delivery Cytotoxicity |
| DOI | 10.1016/j.ejpb.2008.10.015 |
| 英文摘要 | By means of "emulsion-electrospinning", both hydrophobic and hydrophilic drugs, paclitaxel (PTX) and doxorubicin hydrochloride (DOX), were successfully loaded into PEG-PLA nanofiber mats to realize multi-drug delivery. The release behaviors of both the drugs from the same fiber mats were ascribed to their solubility properties and distribution status in the fibers. Due to its high hydrophilicity, DOX was easy to diffuse out from the fibers, and its release rate was always faster than that of hydrophobic PTX. Moreover, the release rate of PTX was accelerated by DOX's release from the same drug-loaded fibers. In vitro cytotoxicity against rat Glioma C6 cells indicated that the dual drug combination showed a higher inhibition and apoptosis against C6 cells than a single drug-loaded system, which suggests the promise for multi-drug delivery on combination therapy. (C) 2008 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000265777400003 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68233]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Jilin Univ, Dept Neurosurg, Changchun 130023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiuling,Chen, Xuesi,Wang, Zhanfeng,et al. Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2009,72(1):18-25. |
| APA | Xu, Xiuling,Chen, Xuesi,Wang, Zhanfeng,&Jing, Xiabin.(2009).Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,72(1),18-25. |
| MLA | Xu, Xiuling,et al."Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 72.1(2009):18-25. |
入库方式： OAI收割
来源：化学研究所
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