Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin
文献类型：期刊论文
| 作者 | Zheng, Li2,3; Ma, Ying2; Zhang, Guangjin1; Yao, Jiannian2; Bassil, Bassem S.4; Kortz, Ulrich4; Keita, Bineta5; de Oliveira, Pedro5; Nadjo, Louis5; Craescu, Constantin T.6 |
| 刊名 | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
 |
| 出版日期 | 2009-12-01 |
| 期号 | 34页码:5189-5193 |
| 关键词 | Gadolinium Polyoxometalates Fluorescence Energy Transfer Protein Structures |
| ISSN号 | 1434-1948 |
| DOI | 10.1002/ejic.200900610 |
| 英文摘要 | Polyoxometalates (POMs) show promising antibacterial, antiviral (particularly anti-HIV), antitumor, and anticancer activities, but the mechanism of these potential therapeutic effects remains to be elucidated at the molecular level. The interaction between the Gd-containing tungstosilicate [Gd(beta(2)-SiW(11)O(39))(2)](13-) and human serum albumin (HSA) was studied by several techniques. Fluorescence spectroscopy showed an energy transfer between the single tryptophan residue of HSA and the POM. Circular dichroism led to the conclusion that the POM significantly altered the secondary structure of HSA. Isothermal titration calorimetry revealed an enthalpy-driven binding reaction between HSA and the POM, resulting in the formation of a 1:1 complex. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) |
| 语种 | 英语 |
| WOS记录号 | WOS:000272825000019 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68271]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Guangjin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Photochem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Jacobs Univ, Sch Sci & Engn, D-28725 Bremen, Germany 5.Univ Paris 11, CNRS, UMR 8000, Chim Phys Lab, F-91405 Orsay, France 6.Ctr Univ Paris Sud, INSERM, U759, Inst Curie Rech, F-91405 Orsay, France |
| 推荐引用方式 GB/T 7714 | Zheng, Li,Ma, Ying,Zhang, Guangjin,et al. Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,2009(34):5189-5193. |
| APA | Zheng, Li.,Ma, Ying.,Zhang, Guangjin.,Yao, Jiannian.,Bassil, Bassem S..,...&Miron, Simona.(2009).Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin.EUROPEAN JOURNAL OF INORGANIC CHEMISTRY(34),5189-5193. |
| MLA | Zheng, Li,et al."Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin".EUROPEAN JOURNAL OF INORGANIC CHEMISTRY .34(2009):5189-5193. |
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来源：化学研究所
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