Cytotoxicity of liver targeted drug-loaded alginate nanoparticles
文献类型：期刊论文
| 作者 | Zhang ChuangNian1; Wang Wei1; Wang ChunHong1; Tian Qin1; Huang Wei1; Yuan Zhi1; Chen XueSi2 |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 52期号:9页码:1382-1387 |
| 关键词 | Liver Targeted Glycyrrhetinic Acid Alginate Cytotoxicity |
| ISSN号 | 1006-9291 |
| DOI | 10.1007/s11426-009-0178-9 |
| 英文摘要 | In this study, novel liver targeted doxorubicin (DOX) loaded alginate (ALG) nanoparticles were prepared by CaCl(2) crosslinking method. Glycyrrhetinic acid (GA, a liver targeted molecule) modified alginate (GA-ALG) was synthesized in a heterogeneous system, and the structure of GA-ALG and the substitution degree of GA were analyzed by (1)H NMR, FT-IR and elemental analysis. The drug release profile under the simulated physiological condition and cytotoxicity experiments of drug-loaded GA-ALG nanoparticles were carried out in vitro. Transmission electron micrographs (TEM) and dynamic light scattering (DLS) analysis showed that drug-loaded GA-ALG nanoparticles have spherical shape structure with the mean hydrodynamic diameter around 214 +/- 11 nm. The drug release was shown to last 20 days, and the MTT assay suggested that drug-loaded GA-ALG nanoparticles had a distinct killing effect on 7703 hepatocellular carcinoma cells. |
| 语种 | 英语 |
| WOS记录号 | WOS:000270191100013 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68323]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yuan Zhi |
| 作者单位 | 1.Nankai Univ, Inst Polymer Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang ChuangNian,Wang Wei,Wang ChunHong,et al. Cytotoxicity of liver targeted drug-loaded alginate nanoparticles[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(9):1382-1387. |
| APA | Zhang ChuangNian.,Wang Wei.,Wang ChunHong.,Tian Qin.,Huang Wei.,...&Chen XueSi.(2009).Cytotoxicity of liver targeted drug-loaded alginate nanoparticles.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(9),1382-1387. |
| MLA | Zhang ChuangNian,et al."Cytotoxicity of liver targeted drug-loaded alginate nanoparticles".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.9(2009):1382-1387. |
入库方式： OAI收割
来源：化学研究所
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