Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release
文献类型：期刊论文
| 作者 | Zhao, Changwen1,2; Zhuang, Xiuli1,3; He, Pan1,2; Xiao, Chunsheng1,2; He, Chaoliang1; Sun, Jingru1; Chen, Xuesi1; Jing, Xiabin1 |
| 刊名 | POLYMER
 |
| 出版日期 | 2009-08-26 |
| 卷号 | 50期号:18页码:4308-4316 |
| 关键词 | Double Sensitive Hydrogel Controlled Release |
| ISSN号 | 0032-3861 |
| DOI | 10.1016/j.polymer.2009.07.010 |
| 英文摘要 | Novel intelligent hydrogels composed of biodegradable and pH-sensitive poly(L-glutamic acid) (PGA) and temperature sensitive poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (PNH) were synthesized and characterized for controlled release of hydrophilic drug. The influence of pH on the equilibrium swelling ratios of the hydrogels was investigated. A higher PNH content resulted in lower equilibrium swelling ratios. Although temperature had little influence on the swelling behaviors of the hydrogels, the changes of optical transmittance of hydrogels as a function of temperature were marked, which showed that the PNH part of hydrogel exhibited hydrophobic property at temperature above the lower critical solution temperature (LCST). The biodegradation rate of the stimuli-sensitive hydrogels in the presence of enzyme was directly proportional to the PGA content. Lysozyme was chosen as a model drug and loaded into the hydrogels. The in vitro drug release experiment was carried out at different pH values and the release data suggested that both the pH and PNH content played important roles in the drug release behaviors of the hydrogels. (C) 2009 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000272959000004 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68331]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhuang, Xiuli |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Waseda Univ, Dept Appl Chem, Tokyo 1698555, Japan |
| 推荐引用方式 GB/T 7714 | Zhao, Changwen,Zhuang, Xiuli,He, Pan,et al. Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release[J]. POLYMER,2009,50(18):4308-4316. |
| APA | Zhao, Changwen.,Zhuang, Xiuli.,He, Pan.,Xiao, Chunsheng.,He, Chaoliang.,...&Jing, Xiabin.(2009).Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release.POLYMER,50(18),4308-4316. |
| MLA | Zhao, Changwen,et al."Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release".POLYMER 50.18(2009):4308-4316. |
入库方式： OAI收割
来源：化学研究所
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