Biodegradable amphiphilic polymer-drug conjugate micelles
文献类型：期刊论文
| 作者 | Hu, Xiuli; Jing, Xiabin |
| 刊名 | EXPERT OPINION ON DRUG DELIVERY
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 6期号:10页码:1079-1090 |
| 关键词 | Biodegradable Nanomedicine Polycarbonate Polylactide Polymer-drug Conjugate Polymeric Micelles |
| ISSN号 | 1742-5247 |
| DOI | 10.1517/17425240903158917 |
| 英文摘要 | The coupling of drugs to macromolecular carriers received an important impetus from Ringsdorf's notion of polymer-drug conjugates. Several water-soluble polymers, poly(ethylene glycol), poly[N-(2-hydroxypropyl) methacrylamidel, poly(L-glutamic acid) and dextran, are studied intensively and have been utilized successfully in clinical research. The promising results arising from clinical trials with polymer-drug conjugates (e.g., paclitaxel, doxorubicin, camptothecins) have provided a firm foundation for other synthetic polymers, especially biodegradable polymers, used as drug delivery vehicles. This review discusses biodegradable polymeric micelles as an alternative drug-conjugate system. Particular focus is on A-B or B-A-B type biodegradable amphiphilic block copolymer such as polylactide, morpholine-2,5-dione derivatives and cyclic carbonates, which can form a core-shell micellar structure, with the hydrophobic drug-binding segment forming the hydrophobic core and the hydrophilic segment as a hydrated outer shell. Polymeric micelles can be designed to avoid uptake by cells of reticuloendothelial system and thus enhance their blood lifetime via the enhanced permeability and retention effect. Active tumor-targeting may be achieved by modifying the micelle surface with specific ligands. The potential application areas are discussed and future challenges are highlighted. |
| 语种 | 英语 |
| WOS记录号 | WOS:000271491200006 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68391]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiuli,Jing, Xiabin. Biodegradable amphiphilic polymer-drug conjugate micelles[J]. EXPERT OPINION ON DRUG DELIVERY,2009,6(10):1079-1090. |
| APA | Hu, Xiuli,&Jing, Xiabin.(2009).Biodegradable amphiphilic polymer-drug conjugate micelles.EXPERT OPINION ON DRUG DELIVERY,6(10),1079-1090. |
| MLA | Hu, Xiuli,et al."Biodegradable amphiphilic polymer-drug conjugate micelles".EXPERT OPINION ON DRUG DELIVERY 6.10(2009):1079-1090. |
入库方式： OAI收割
来源：化学研究所
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