Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction
文献类型：期刊论文
| 作者 | Qi, Li1,2; Cui, Kai1; Qiao, Juan1; Yang, Gengliang2; Chen, Yi1 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 32期号:9页码:1480-1486 |
| 关键词 | Cyclopentenone Imidazole-catalyzed Baylis-hillman Reaction Mekc P-nitrobenzaldehyde |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.200800612 |
| 英文摘要 | A facile, fast and high efficiency micellar EKC has been explored for the analysis and UV detection of p-nitrobenzaldehyde and 2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one with a buffer electrolyte of 30.0 mM tetraborate and 50.0 mM sodium taurodeoxycholate at pH 9.3. Under the optimal conditions, a linear range 10(-2) to 5.0 x 10(2) MM from 7.8 x for those analytes (r(2) > 0.99) was achieved. The LOD was 3.9 mu M for 2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one and 7.8 mu M for p-nitrobenzaldehyde, respectively (S/N = 3). The applicability of this new method for the analysis of reactants (p-nitrobenzaldehyde and cyclopent-2-enone), catalysts (imidazole or N-methyl imidazole or 1-benzyl-imidazole) and product (2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one) on offline Baylis-Hillman reaction was examined. The relationship between the reaction time and the amount of product has been studied. Meanwhile, three different kinds of catalysts were investigated for getting the desired moderate to good amount products. It was found that comparing with N-methyl imidazole or 1-benzyl-imidazole catalyst, imidazole-catalyzed reaction could produce more products within the same reaction time. Furthermore, the results indicated that the rate law for the investigated Baylis-Hillman reaction was second-order reaction. The rate constant for the reaction is 1.34 (+/- 0.01) x 10(-3) mol m(3)/s. |
| 语种 | 英语 |
| WOS记录号 | WOS:000266341200028 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68415]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Lab Analyt Chem Life, Beijing Normal Lab Mol Sci, Beijing 100190, Peoples R China 2.Hebei Univ, Coll Pharm, Baoding, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Li,Cui, Kai,Qiao, Juan,et al. Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction[J]. JOURNAL OF SEPARATION SCIENCE,2009,32(9):1480-1486. |
| APA | Qi, Li,Cui, Kai,Qiao, Juan,Yang, Gengliang,&Chen, Yi.(2009).Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction.JOURNAL OF SEPARATION SCIENCE,32(9),1480-1486. |
| MLA | Qi, Li,et al."Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction".JOURNAL OF SEPARATION SCIENCE 32.9(2009):1480-1486. |
入库方式： OAI收割
来源：化学研究所
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