In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy
文献类型：期刊论文
| 作者 | Mao, Youdong1,2,3; Sun, Quanmei1; Wang, Xiufeng4; Ouyang, Qi5; Han, Li6; Jiang, Lei7; Han, Dong1 |
| 刊名 | APPLIED PHYSICS LETTERS
 |
| 出版日期 | 2009-07-06 |
| 卷号 | 95期号:1 |
| ISSN号 | 0003-6951 |
| DOI | 10.1063/1.3167546 |
| 英文摘要 | Atomic force microscopy (AFM) is difficult to achieve in living mammals but is necessary for understanding mechanical properties of tissues in their native form in organisms. Here we report in vivo nanomechanical imaging of blood-vessel tissues directly in living mammalians by AFM combined with surgical operations. Nanomechanical heterogeneity of blood vessels is observed across the diverse microenvironments of the same tissues in vivo. This method is further used to measure the counteractive nanomechanical changes in real time during drug-induced vasodilation and vasoconstriction in vivo, demonstrating appealing potential in characterization of in vivo nanomechanical dynamics of native tissues. (C) 2009 American Institute of Physics. [DOI:10.1063/1.3167546] |
| 语种 | 英语 |
| WOS记录号 | WOS:000267983200102 |
| 出版者 | AMER INST PHYSICS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68449]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Han, Dong |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China 2.Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA 3.Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA 4.Tsinghua Univ, Dept Phys, Beijing 100084, Peoples R China 5.Peking Univ, Sch Phys, Beijing 100871, Peoples R China 6.Chinese Acad Sci, Inst Elect Engn, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Youdong,Sun, Quanmei,Wang, Xiufeng,et al. In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy[J]. APPLIED PHYSICS LETTERS,2009,95(1). |
| APA | Mao, Youdong.,Sun, Quanmei.,Wang, Xiufeng.,Ouyang, Qi.,Han, Li.,...&Han, Dong.(2009).In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy.APPLIED PHYSICS LETTERS,95(1). |
| MLA | Mao, Youdong,et al."In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy".APPLIED PHYSICS LETTERS 95.1(2009). |
入库方式： OAI收割
来源：化学研究所
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