Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin
文献类型：期刊论文
| 作者 | Ren, Lixia1; He, Lihong1,2; Sun, Tongchen1; Dong, Xia1; Chen, Yongming1; Huang, Jin3; Wang, Chun4 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2009-09-09 |
| 卷号 | 9期号:9页码:902-910 |
| 关键词 | Cyclodextrins Drug Delivery Grafted Copolymers Hydrogels Stimulus Responsive |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.200900021 |
| 英文摘要 | Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with a-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000270283800011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68577]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Yongming |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Div Polymer Sci & Mat, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN USA 3.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China 4.Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA |
| 推荐引用方式 GB/T 7714 | Ren, Lixia,He, Lihong,Sun, Tongchen,et al. Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin[J]. MACROMOLECULAR BIOSCIENCE,2009,9(9):902-910. |
| APA | Ren, Lixia.,He, Lihong.,Sun, Tongchen.,Dong, Xia.,Chen, Yongming.,...&Wang, Chun.(2009).Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin.MACROMOLECULAR BIOSCIENCE,9(9),902-910. |
| MLA | Ren, Lixia,et al."Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin".MACROMOLECULAR BIOSCIENCE 9.9(2009):902-910. |
入库方式： OAI收割
来源：化学研究所
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