In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)
文献类型：期刊论文
| 作者 | Zhang, Peibiao1; Hong, Zhongkui1; Yu, Ting2; Chen, Xuesi1; Jing, Xiabin1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:1页码:58-70 |
| 关键词 | Poly(Lactide-co-glycolide) Hydroxyapatite Nanocomposite Mineralization Osteogenesis Bone Repair |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2008.08.041 |
| 英文摘要 | Nanocomposite of hydroxyapatite (HAP) surface-grafted with poly(L-lactide) (PLLA) (g-HAP) shows a wide application for bone fixation materials due to its improved interface compatibility, mechanical property and biocompatibility in our previous study. In this paper, a 3-D porous scaffold of g-HAP/poly (lactide-co-glycolide) (PLGA) was fabricated using the solvent casting/particulate leaching method to investigate its applications in bone replacement and tissue engineering. The composite of un-grafted HAP/PLGA and neat PLGA were used as controls. Their in vivo mineralization and osteogenesis were investigated by intramuscular implantation and replacement for repairing radius defects of rabbits. After surface modification, more uniform distribution of g-HAP particles but a lower calcium exposure on the surface of g-HAP/PLGA was observed. Intramuscular implantation study showed that the scaffold of g-HAP/PLGA was more stable than that of PLGA, and exhibited similar mineralization and biodegradability to HAP/PLGA at the 12-20 weeks post-surgery. The implantation study for repairing critical radius defects showed that the scaffold of g-HAP/PLGA exhibited rapid and strong mineralization and osteo-conductivity, and the incorporation of BMP-2 could enhance the osteogenic process of the composite implant. The new bone formation with the intact structure of a long bone was guided by the implant of g-HAP/PLGA. (C) 2008 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261139100008 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68609]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peibiao,Hong, Zhongkui,Yu, Ting,et al. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)[J]. BIOMATERIALS,2009,30(1):58-70. |
| APA | Zhang, Peibiao,Hong, Zhongkui,Yu, Ting,Chen, Xuesi,&Jing, Xiabin.(2009).In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide).BIOMATERIALS,30(1),58-70. |
| MLA | Zhang, Peibiao,et al."In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)".BIOMATERIALS 30.1(2009):58-70. |
入库方式： OAI收割
来源：化学研究所
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