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Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs
文献类型：期刊论文
| 作者 | Zhang, Liming1,2,3; Xia, Jingguang1; Zhao, Qinghuan1; Liu, Liwei1; Zhang, Zhijun1 |
| 刊名 | SMALL
 |
| 出版日期 | 2010-02-22 |
| 卷号 | 6期号:4页码:537-544 |
| 关键词 | Cancer Therapy Cytotoxicity Drug Delivery Graphene Oxide Nanomaterials |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.200901680 |
| 英文摘要 | A simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by covalent binding of folic acid (FA) molecules to the NGO, thus allowing it to specifically target MCF-7 cells, human breast cancer cells with FA receptors. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT), onto the FA-conjugated NGO (FA-NGO) via pi-pi stacking and hydrophobic interactions is investigated. It is demonstrated that FA-NGO loaded with the two anticancer drugs shows specific targeting to MCF-7 cells, and remarkably high cytotoxicity compared to NGO loaded with either DOX or CPT only. Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene-based nanocarriers may find widespread application in biomedicine. |
| 语种 | 英语 |
| WOS记录号 | WOS:000275260100009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68723]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Zhijun |
| 作者单位 | 1.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Suzhou 215125, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Liming,Xia, Jingguang,Zhao, Qinghuan,et al. Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs[J]. SMALL,2010,6(4):537-544. |
| APA | Zhang, Liming,Xia, Jingguang,Zhao, Qinghuan,Liu, Liwei,&Zhang, Zhijun.(2010).Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs.SMALL,6(4),537-544. |
| MLA | Zhang, Liming,et al."Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs".SMALL 6.4(2010):537-544. |
入库方式： OAI收割
来源：化学研究所
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