The lectin binding and targetable cellular uptake of lipid-coated polysaccharide microcapsules
文献类型：期刊论文
| 作者 | Qi, Wei1,2; Wang, Anhe1; Yang, Yang3; Du, Mingchun1; Bouchu, Marie Noelle4; Boullanger, Paul4; Li, Junbai1,3 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:11页码:2121-2127 |
| ISSN号 | 0959-9428 |
| DOI | 10.1039/b920469p |
| 英文摘要 | In this study, a capsule/lipid composite system has been developed for targeted delivery of small molecular drugs (daunorubicin hydrochloride, DNR) to cancer cells. The lipid coating not only provides a sealed barrier to prevent the leakage of the encapsulated drugs, but also can be used as a means to attach biological functionality to capsule surfaces. A neoglycolipid incorporated into the supported lipid membrane has shown high affinity in lectin binding studies (concanavalin A), while a folate-linked lipid in the lipid membrane provides a functional capacity to target cancer cells (MCF-7). Folate-targeted capsules are much more efficient than the non-targeted capsules in delivering DNR to MCF-7 cells. The system provides a way to create a biomimetic delivery vehicle for the effective and selective targeting of drugs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000275099900012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68875]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Int Joint Lab,BNLMS, Beijing 100190, Peoples R China 2.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 4.Univ Lyon 1, CNRS, ICBMS, Lab Chim Organ Glycochim 2,UMR 5246, F-69622 Villeurbanne, France |
| 推荐引用方式 GB/T 7714 | Qi, Wei,Wang, Anhe,Yang, Yang,et al. The lectin binding and targetable cellular uptake of lipid-coated polysaccharide microcapsules[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(11):2121-2127. |
| APA | Qi, Wei.,Wang, Anhe.,Yang, Yang.,Du, Mingchun.,Bouchu, Marie Noelle.,...&Li, Junbai.(2010).The lectin binding and targetable cellular uptake of lipid-coated polysaccharide microcapsules.JOURNAL OF MATERIALS CHEMISTRY,20(11),2121-2127. |
| MLA | Qi, Wei,et al."The lectin binding and targetable cellular uptake of lipid-coated polysaccharide microcapsules".JOURNAL OF MATERIALS CHEMISTRY 20.11(2010):2121-2127. |
入库方式： OAI收割
来源：化学研究所
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