Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst
文献类型：期刊论文
| 作者 | Tang, Weijun1; Sun, Yawei1; Xu, Lijin1; Wang, Tianli2; Fan, Qinghua2; Lam, Kim-Hung3,4; Chan, Albert S. C.3,4 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 8期号:15页码:3464-3471 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c002668a |
| 英文摘要 | The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl](2) in THF resulted in a highly efficient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings (0.05-0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h(-1)) and productivities (TON up to 43000). The same catalyst was also successfully applied to the asymmetric hydrogenation of trisubstituted pyridines with nearly quantitative yields and up to 98% ee. In these two reactions, the addition of I(2) additive is indispensable; but the amount of I(2) has a different effect on catalytic performance. |
| 语种 | 英语 |
| WOS记录号 | WOS:000279913700015 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/68973]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, Lijin |
| 作者单位 | 1.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China 4.Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Weijun,Sun, Yawei,Xu, Lijin,et al. Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(15):3464-3471. |
| APA | Tang, Weijun.,Sun, Yawei.,Xu, Lijin.,Wang, Tianli.,Fan, Qinghua.,...&Chan, Albert S. C..(2010).Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst.ORGANIC & BIOMOLECULAR CHEMISTRY,8(15),3464-3471. |
| MLA | Tang, Weijun,et al."Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst".ORGANIC & BIOMOLECULAR CHEMISTRY 8.15(2010):3464-3471. |
入库方式： OAI收割
来源：化学研究所
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