Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc] from D-glucuronolactone: the first sub-micromolar inhibitor of alpha-N-acetylgalactosaminidases
文献类型：期刊论文
| 作者 | Best, Daniel1; Chairatana, Phoom1; Glawar, Andreas F. G.1,2; Crabtree, Elizabeth1,2; Butters, Terry D.2; Wilson, Francis X.5; Yu, Chu-Yi4; Wang, Wu-Bao4; Jia, Yue-Mei4; Adachi, Isao3 |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2010-04-28 |
| 卷号 | 51期号:17页码:2222-2224 |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2010.02.063 |
| 英文摘要 | 2-Acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from D-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of alpha-N-acetyl-galactosaminidases (K(i) 0.081 mu M from chicken liver, K(i) 0.136 mu M from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer L-DGJNAc is a very weak but non-competitive inhibitor of beta-hexosaminidases. (C) 2010 Published by Elsevier Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000276588100003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69099]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fleet, George W. J. |
| 作者单位 | 1.Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England 2.Univ Oxford, Oxford Glycobiol Inst, Oxford OX1 3QU, England 3.Toyama Univ, Dept Hosp Pharm, Toyama 9300194, Japan 4.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 5.Summit PLC, Abingdon OX14 4RY, Oxon, England |
| 推荐引用方式 GB/T 7714 | Best, Daniel,Chairatana, Phoom,Glawar, Andreas F. G.,et al. Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc] from D-glucuronolactone: the first sub-micromolar inhibitor of alpha-N-acetylgalactosaminidases[J]. TETRAHEDRON LETTERS,2010,51(17):2222-2224. |
| APA | Best, Daniel.,Chairatana, Phoom.,Glawar, Andreas F. G..,Crabtree, Elizabeth.,Butters, Terry D..,...&Fleet, George W. J..(2010).Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc] from D-glucuronolactone: the first sub-micromolar inhibitor of alpha-N-acetylgalactosaminidases.TETRAHEDRON LETTERS,51(17),2222-2224. |
| MLA | Best, Daniel,et al."Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc] from D-glucuronolactone: the first sub-micromolar inhibitor of alpha-N-acetylgalactosaminidases".TETRAHEDRON LETTERS 51.17(2010):2222-2224. |
入库方式： OAI收割
来源：化学研究所
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