Chiral Primary Amine Catalyzed Asymmetric Epoxidation of alpha-Substituted Acroleins
文献类型：期刊论文
| 作者 | Li, Jiuyuan1; Fu, Niankai1; Zhang, Long1; Zhou, Pengxin2,3; Luo, Sanzhong1; Cheng, Jin-Pei2,3 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2010-12-01 |
| 期号 | 35页码:6840-6849 |
| 关键词 | Asymmetric Catalysis Epoxidation Amines Chirality |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201001117 |
| 英文摘要 | 1,1-Disubstituted terminal alkenes remain challenging substrates in asymmetric epoxidation reactions. In this study, chiral primary amines are shown to catalyze the asymmetric epoxidation of alpha-substituted acroleins, a versatile type of 1,1-disubstituted terminal alkene. Among various chiral primary amines explored, the chiral primary-tertiary vicinal diamine derived from trans-1,2-diphenylethane-1,2-diamine is identified as the optimal catalyst, which, in combination with 5-sulfosalicyclic acid (5-SSA), exhibits good catalytic activity (up to 95% yield) and enantioselectivity (up to 88% ee). Aqueous 2 M sodium chloride was found to be the optimal reaction media. |
| 语种 | 英语 |
| WOS记录号 | WOS:000285310700018 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69175]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Sanzhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China 2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 3.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiuyuan,Fu, Niankai,Zhang, Long,et al. Chiral Primary Amine Catalyzed Asymmetric Epoxidation of alpha-Substituted Acroleins[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2010(35):6840-6849. |
| APA | Li, Jiuyuan,Fu, Niankai,Zhang, Long,Zhou, Pengxin,Luo, Sanzhong,&Cheng, Jin-Pei.(2010).Chiral Primary Amine Catalyzed Asymmetric Epoxidation of alpha-Substituted Acroleins.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(35),6840-6849. |
| MLA | Li, Jiuyuan,et al."Chiral Primary Amine Catalyzed Asymmetric Epoxidation of alpha-Substituted Acroleins".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .35(2010):6840-6849. |
入库方式： OAI收割
来源：化学研究所
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