Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction
文献类型：期刊论文
| 作者 | Yue, Jun1,2; Li, Xiaoyuan1; Mo, Guojun1,2; Wang, Rui1,2; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | MACROMOLECULES
 |
| 出版日期 | 2010-12-14 |
| 卷号 | 43期号:23页码:9645-9654 |
| ISSN号 | 0024-9297 |
| DOI | 10.1021/ma101960d |
| 英文摘要 | Two kinds of amphiphilic block copolymers, allyoxyl poly(ethylene glycol)-b-poly(L-lactide) and methoxyl poly(ethylene glycol)-b-poly(L-lactide-co-2-methyl-2-allyloxycarbonyl-propylene carbonate), were synthesized in a controllable manner. Radical mediated thiol-ene reaction was utilized to modify these two precursor block copolymers with three model mercaptans. Highly efficient and quantitative modification under UV light without adding any photoinitiators was observed by H-1 NMR spectra of the products collected at specific time points. The reaction rate was mainly dependent on molar ratio of thiol to vinyl in feeding. Quantitative transformation of the vinyl groups in both block copolymers was realized in 0.5-2 h when using excessive thiol with respect to vinyl. Using commercially available mercaptans, different functional groups were introduced into the block copolymers, thus realizing modular functionalization of target block copolymers. This method of functionalization effectively avoided traditional protection/deprotection procedures, thus greatly simplifying the process of functionalization. Precipitation and dialysis procedures were proved efficient to eliminate excess mercaptans, thus endowing the material with good biocompatibility. |
| 语种 | 英语 |
| WOS记录号 | WOS:000284967000012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69209]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Jun,Li, Xiaoyuan,Mo, Guojun,et al. Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction[J]. MACROMOLECULES,2010,43(23):9645-9654. |
| APA | Yue, Jun,Li, Xiaoyuan,Mo, Guojun,Wang, Rui,Huang, Yubin,&Jing, Xiabin.(2010).Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction.MACROMOLECULES,43(23),9645-9654. |
| MLA | Yue, Jun,et al."Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction".MACROMOLECULES 43.23(2010):9645-9654. |
入库方式： OAI收割
来源：化学研究所
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