Fullerene-Conjugated Doxorubicin in Cells
文献类型：期刊论文
| 作者 | Liu, Jia-Hui1,2,3; Cao, Li1,2; Luo, Pengju G.1,2; Yang, Sheng-Tao1,2,3; Lu, Fushen1,2; Wang, Haifang4; Meziani, Mohammed J.1,2; Haque, Sk. Anwarul1,2; Liu, Yuanfang3,4; Lacher, Sebastian1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 2期号:5页码:1384-1389 |
| 关键词 | Fullerenes Doxorubicin Conjugates Fluorescence Bioimaging Cells |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am100037y |
| 英文摘要 | The conjugation of fullerene with well-established drug molecules has been a representative strategy to impart fullerene-specific properties for improved formulation. However, conjugates involving fullerenes or other nanomaterials often differ significantly from the free drug molecules in cellular uptake and distributions. For the highly effective anticancer drug doxorubicin (DOX), its strong absorption and fluorescence in the visible spectral region enable the tracking of DOX-containing conjugates by optical techniques. In this work, a stoimetrically and structurally well-defined fullerene-DOX conjugate was studied in terms of fluorescence microscopy, including the fluorescence imaging with two-photon excitation, to examine the uptake and distribution in human breast cancer cells. The results suggested that the conjugate was distributed mostly in the cytoplasm, significantly different from free DOX molecules (predominantly in the cell nucleus, as already reported in the literature). Mechanistic implications of the results are discussed. Also discussed are potentials of conjugated DOX species as self-labeled fluorescent probes in bioimaging and other mechanistic investigations on drug delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000277977400018 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69215]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Pengju G. |
| 作者单位 | 1.Clemson Univ, Dept Chem, Clemson, SC 29634 USA 2.Clemson Univ, Lab Emerging Mat & Technol, Clemson, SC 29634 USA 3.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 4.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jia-Hui,Cao, Li,Luo, Pengju G.,et al. Fullerene-Conjugated Doxorubicin in Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2010,2(5):1384-1389. |
| APA | Liu, Jia-Hui.,Cao, Li.,Luo, Pengju G..,Yang, Sheng-Tao.,Lu, Fushen.,...&Sun, Ya-Ping.(2010).Fullerene-Conjugated Doxorubicin in Cells.ACS APPLIED MATERIALS & INTERFACES,2(5),1384-1389. |
| MLA | Liu, Jia-Hui,et al."Fullerene-Conjugated Doxorubicin in Cells".ACS APPLIED MATERIALS & INTERFACES 2.5(2010):1384-1389. |
入库方式： OAI收割
来源：化学研究所
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