A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing
文献类型：期刊论文
| 作者 | Yang, Chao1,3,5; Xu, Ling1,2,3; Zhou, Ying1,3; Zhang, Xiangmei3; Huang, Xin1,3; Wang, Min2; Han, Ye3; Zhai, Maolin2; Wei, Shicheng3,4; Li, Jiuqiang2 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2010-11-11 |
| 卷号 | 82期号:4页码:1297-1305 |
| 关键词 | Gelatin Carboxymethyl Chitosan Hydrogel Radiation Crosslinking Wound Healing |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2010.07.013 |
| 英文摘要 | A series of hydrogels were fabricated from an aqueous solution of gelatin and carboxymethyl chitosan (CM-chitosan) by radiation-induced-crosslinking at ambient temperature. Several physicochemical and biological properties of the hydrogels were investigated to evaluate their potential as wound healing materials. By increasing the CM-chitosan content in the hybrid hydrogels, their swelling ability increased significantly, while the compressive modulus decreased. The miscibility between gelatin and CM-chitosan molecules led to a semi-interpenetrate network after crosslinking. Observed by SEM, scaffolds with a homogeneous interconnected pore structure were obtained after lyophilizing the hydrogels. The enzyme degradation rate of the hydrogels was controlled by adjusting the procedure, which could be matched to the healing rate of the wound. Furthermore, the gelatin/CM-chitosan hydrogels promoted cell attachment and rapid growth of fibroblasts on the material. Due to the high water absorption capacity, a similar compressive modulus with soft tissue, controllable biodegradation, and excellent biocompatibility, the gelatin/CM-chitosan hybrid hydrogels have potential as skin scaffolds and wound healing materials. (C) 2010 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000283042100038 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69347]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, Ling |
| 作者单位 | 1.Peking Univ, Dept Energy & Resources Engn, Coll Engn, Beijing 100871, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 4.Peking Univ, Sch Stomatol, Beijing 100044, Peoples R China 5.Peking Univ, Dept Appl Linguist, Hlth Sci Ctr, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Chao,Xu, Ling,Zhou, Ying,et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing[J]. CARBOHYDRATE POLYMERS,2010,82(4):1297-1305. |
| APA | Yang, Chao.,Xu, Ling.,Zhou, Ying.,Zhang, Xiangmei.,Huang, Xin.,...&Li, Jiuqiang.(2010).A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing.CARBOHYDRATE POLYMERS,82(4),1297-1305. |
| MLA | Yang, Chao,et al."A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing".CARBOHYDRATE POLYMERS 82.4(2010):1297-1305. |
入库方式： OAI收割
来源：化学研究所
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