Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers
文献类型：期刊论文
| 作者 | Yang, Yang1; Song, Weixing1; Wang, Anhe2; Zhu, Pengli2; Fei, Jinbo2; Li, Junbai1,2 |
| 刊名 | PHYSICAL CHEMISTRY CHEMICAL PHYSICS
 |
| 出版日期 | 2010 |
| 卷号 | 12期号:17页码:4418-4422 |
| ISSN号 | 1463-9076 |
| DOI | 10.1039/b924370d |
| 英文摘要 | This paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers ( hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy. |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000276896000021 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69387]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, BNLMS, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yang,Song, Weixing,Wang, Anhe,et al. Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2010,12(17):4418-4422. |
| APA | Yang, Yang,Song, Weixing,Wang, Anhe,Zhu, Pengli,Fei, Jinbo,&Li, Junbai.(2010).Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,12(17),4418-4422. |
| MLA | Yang, Yang,et al."Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 12.17(2010):4418-4422. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。