Biological Activity of a Cholesterol Modified Fullerene/gamma-Cyclodextrin Inclusion Complex
文献类型：期刊论文
| 作者 | Gao Yun-Yan1; Liu Li-Hua1; Ou Zhi-Ze1; Li Yi2; Yang Guo-Qiang3; Wang Xue-Song2 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 26期号:2页码:495-501 |
| 关键词 | Fullerene Cyclodextrin Inclusion Complex Serum Albumin Dna Cleavage |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB20100238 |
| 英文摘要 | A cholesterol modified fullerene (CHL-C-60) was synthesized using the Bingel-Hirsch reaction and was characterized by nuclear magnetic resonance (NMR), mass spectra (MS), elemental analysis (EA). Results of UV-Vis spectrum and fluorescence spectrum indicate that CHL-C-60 forms an inclusion complex with gamma-cyclodextrin (gamma-CD) due to the strong interaction between gamma-cyclodextrin and the steroid ring. The water solubility of CHL-C-60 is enhanced significantly. CHL-C-60 can dissociate from cyclodextrin and subsequently bind to human serum albumin (HSA) and bovine serum albumin (BSA) with association constants of 5.73 x 10(4) and 7.05 x 10(4) L.moL(-1), respectively. The efficiency of desoxyribonucleic acid (DNA) photocleavage for CHL-C-omega/gamma-CD is as high as 60.5% under anaerobic conditions, which is caused by photoinduced electron transfer from pBR322 plasmid DNA to CHL-C-60. |
| 语种 | 英语 |
| WOS记录号 | WOS:000274701200036 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69619]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gao Yun-Yan |
| 作者单位 | 1.Northwestern Polytech Univ, Dept Appl Chem, Sch Sci, Xian 710072, Peoples R China 2.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao Yun-Yan,Liu Li-Hua,Ou Zhi-Ze,et al. Biological Activity of a Cholesterol Modified Fullerene/gamma-Cyclodextrin Inclusion Complex[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(2):495-501. |
| APA | Gao Yun-Yan,Liu Li-Hua,Ou Zhi-Ze,Li Yi,Yang Guo-Qiang,&Wang Xue-Song.(2010).Biological Activity of a Cholesterol Modified Fullerene/gamma-Cyclodextrin Inclusion Complex.ACTA PHYSICO-CHIMICA SINICA,26(2),495-501. |
| MLA | Gao Yun-Yan,et al."Biological Activity of a Cholesterol Modified Fullerene/gamma-Cyclodextrin Inclusion Complex".ACTA PHYSICO-CHIMICA SINICA 26.2(2010):495-501. |
入库方式： OAI收割
来源：化学研究所
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