Autoxidation and Prooxidation Mechanisms of Danshensu
文献类型：期刊论文
| 作者 | Xu Yuan-Chao1; Yang Yi1; Du Li-Bo2; Shen Jian-Gang3; Wang Guang-Qing2; He Zeng2; Tian Qiu2; Liu Yang2 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 26期号:7页码:1737-1741 |
| 关键词 | Danshensu Hydrogen Peroxide Electrode Autoxidation Prooxidation Superoxide Anion |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB20100710 |
| 英文摘要 | A hydrogen peroxide (H2O2) electrode and electron spin resonance (ESR) methods were used to continuously monitor and analyze the autoxidation and prooxidation of Danshensu in aqueous solutions with various pH values. We found that Danshensu exhibited obvious autoxidative activity in alkalescence buffer solutions (pH=8.5) and the presence of Cu2+ evidently accelerated the generation of H2O2. The primary product of the autoxidation was a superoxide anion radical (O-2(-center dot)) and then it could be converted into H2O2. The autoxidation of Danshensu was totally inhibited under weak acidic conditions (pH=6.5) and a partial prooxidation of Danshensu occurred in the presence of cupric ion. However, under physiological conditions (pH=7.4), the autoxidation of Danshensu was very slow and its prooxidation, initiated by Cu2+, was very limited. Consequently, the autoxidation and prooxidation of Danshensu cannot be completely ignored when used in clinical practice especially under alkaline body fluid conditions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000279776400002 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69747]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang Yi |
| 作者单位 | 1.Beijing Univ Chem Technol, Sch Sci, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Yuan-Chao,Yang Yi,Du Li-Bo,et al. Autoxidation and Prooxidation Mechanisms of Danshensu[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(7):1737-1741. |
| APA | Xu Yuan-Chao.,Yang Yi.,Du Li-Bo.,Shen Jian-Gang.,Wang Guang-Qing.,...&Liu Yang.(2010).Autoxidation and Prooxidation Mechanisms of Danshensu.ACTA PHYSICO-CHIMICA SINICA,26(7),1737-1741. |
| MLA | Xu Yuan-Chao,et al."Autoxidation and Prooxidation Mechanisms of Danshensu".ACTA PHYSICO-CHIMICA SINICA 26.7(2010):1737-1741. |
入库方式： OAI收割
来源：化学研究所
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