PREPARATION AND CHARATERIZATION OF THE DRUG LOADED MICROCAPSULES WITH THERMO- AND MAGNETIC-SENSITITIES
文献类型：期刊论文
| 作者 | Rong Jianhua1; Duan Taiwei1; Wen Hongge1; Qu Xiaozhong2 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2010-04-20 |
| 期号 | 4页码:484-489 |
| 关键词 | Microcapsule Drug Delivery Magnetic Nanoparticle Lipid Thermo-sensitivity |
| ISSN号 | 1000-3304 |
| 英文摘要 | A novel targeted carrier of drug loaded microcapsules with thermo- and magnetic-sensitivities was fabricated by the layer-by-layer self-assembly technique. Natural polyelectrolytes such as chitosan and sodium alginate, magnetic nanoparticles Fe(3)O(4), and lipid dipalmitoyl-sn-glycero-3-phosphate (monosodium salt) (DPPA), (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) (DPPC) or their composite 10% DPPA/90% DPPC were used as components of microcapsule. The structure, drug loading and thermo-sensitive drug release of the microcapsules were characterized by TEM, SEM, laser scanning confocal microscope and ultraviolet spectrophotometer. The results showed that positive Fe(3)O(4) nanoparticles with superparamagnetic property were successfully assembled on the microcapsules, which could be effectively trapped by solid permanent magnet. The drug entrapment efficiency is affected by the drug concentration and the temperature. The highest drug loading amount could reach to 22.40% when the temperature reached 60 degrees C. The drug release properties of microcapsules were measured at 37 degrees C and 40 degrees C, which were lower and higher than the phase transition of DPPA lipid film respectively. The results showed that the microcapsules with lipid film were sensitive to temperature. The thermo-sensitive lipid film assembled on the surface of microcapsule could effectively prevent drug from being released at the lower temperature, which will favor the drug to reach the targeted site with less drug loss. |
| 语种 | 英语 |
| WOS记录号 | WOS:000277591700017 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69813]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Rong Jianhua |
| 作者单位 | 1.Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Rong Jianhua,Duan Taiwei,Wen Hongge,et al. PREPARATION AND CHARATERIZATION OF THE DRUG LOADED MICROCAPSULES WITH THERMO- AND MAGNETIC-SENSITITIES[J]. ACTA POLYMERICA SINICA,2010(4):484-489. |
| APA | Rong Jianhua,Duan Taiwei,Wen Hongge,&Qu Xiaozhong.(2010).PREPARATION AND CHARATERIZATION OF THE DRUG LOADED MICROCAPSULES WITH THERMO- AND MAGNETIC-SENSITITIES.ACTA POLYMERICA SINICA(4),484-489. |
| MLA | Rong Jianhua,et al."PREPARATION AND CHARATERIZATION OF THE DRUG LOADED MICROCAPSULES WITH THERMO- AND MAGNETIC-SENSITITIES".ACTA POLYMERICA SINICA .4(2010):484-489. |
入库方式： OAI收割
来源：化学研究所
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