Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities
文献类型：期刊论文
| 作者 | Cao, Qing2,3; Xu, Yan2; Liu, Feng3; Svec, Frantisek1,2; Frechet, Jean M. J.1,2 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 82期号:17页码:7416-7421 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/ac1015613 |
| 英文摘要 | Newly developed porous polymer monolithic capillary columns modified with gold nanoparticles coated with exchangeable functionalities allow easy switching of separation modes by a simple ligand exchange process. These columns are prepared from a poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith through reaction of its epoxide moieties with cysteamine to afford a monolith rich in surface thiol groups. Gold nanoparticles prepared via in situ reduction of chloroauric acid within the column become attached to the surface of the pores of the monolith. Alternatively, a solution of colloidal gold nanoparticles can be pumped through the thiol modified column to achieve their attachment. While the first approach is faster, it affords a lower coverage of nanoparticles than the second method, while both methods preserve the excellent hydrodynamic properties that are typical of the monolithic columns. Functionalization of the surface of the bound gold nanoparticles is then carried out using low molecular weight thiol-containing surface ligands. The dynamic nature of the bond between gold and these surface ligands enables the replacement of one surface ligand by another through a simple solution exchange process. This novel approach expands the application range of monoliths as a single column can now be used in different separations modes. Applications of the columns with exchangeable chemistries are demonstrated with the capillary electrochromatographic separation of peptides and the nano-high-pressure liquid chromatography (HPLC) separation of proteins in both reversed phase and ion exchange modes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000281306000050 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69891]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Frechet, Jean M. J. |
| 作者单位 | 1.EO Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA 2.Univ Calif Berkeley, Coll Chem, Berkeley, CA 94720 USA 3.Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci,Minist Educ, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Qing,Xu, Yan,Liu, Feng,et al. Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities[J]. ANALYTICAL CHEMISTRY,2010,82(17):7416-7421. |
| APA | Cao, Qing,Xu, Yan,Liu, Feng,Svec, Frantisek,&Frechet, Jean M. J..(2010).Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities.ANALYTICAL CHEMISTRY,82(17),7416-7421. |
| MLA | Cao, Qing,et al."Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities".ANALYTICAL CHEMISTRY 82.17(2010):7416-7421. |
入库方式： OAI收割
来源：化学研究所
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