Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations
文献类型：期刊论文
| 作者 | Huang Yong-Qi; Liu Zhi-Rong |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 26期号:8页码:2061-2072 |
| 关键词 | Intrinsically Disordered Protein Protein Folding Protein Interaction Molecular Recognition Protein Structure Prediction Drug Design |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB20100644 |
| 英文摘要 | Intrinsically disordered proteins (IDPs) are a new class of proteins which lack a unique tertiary structure under native conditions while possessing essential biological functions. They take part in various physiological processes such as signal transduction, transcription and translation regulation, and protein modification. The discovery of IDPs challenges the conventional protein "sequence-structure-function" paradigm. In this review, we first overview the history of the conventional protein paradigm and the discovery of IDPs. Then we discuss the characteristics of IDPs in terms of sequence, structure, and biological function. Taking molecular recognition processes as an example, we further introduce current opinions on the advantages of IDPs in binding. Finally, we analyze possible applications of the study of IDPs such as further understanding the protein folding mechanism, improving protein structure determination, providing new clues for protein design and new targets for drug design. The current status of IDPs study in China is also briefly presented. |
| 语种 | 英语 |
| WOS记录号 | WOS:000280259900002 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/69931]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu Zhi-Rong |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Ctr Theoret Biol, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang Yong-Qi,Liu Zhi-Rong. Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(8):2061-2072. |
| APA | Huang Yong-Qi,&Liu Zhi-Rong.(2010).Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations.ACTA PHYSICO-CHIMICA SINICA,26(8),2061-2072. |
| MLA | Huang Yong-Qi,et al."Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations".ACTA PHYSICO-CHIMICA SINICA 26.8(2010):2061-2072. |
入库方式： OAI收割
来源：化学研究所
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