Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis
文献类型：期刊论文
| 作者 | Wang Dexian1; Wang Meixiang1,2 |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 22期号:7页码:1397-1402 |
| 关键词 | Rhodococcus Erythropolis Aj270 Biocatalysis And Biotransformation Enantioselectivity Nitrites Amides |
| ISSN号 | 1005-281X |
| 英文摘要 | Enantioselective biotransformation of nitriles using nitrile hydrolyzing microbial whole cell catalysts is a powerful method for the synthesis of highly enantiopure carboxylic acids and amide derivatives. In this article, progress of Rhodococcus erythropolis AJ270-catalyzed enantioselective biotransformations of nitriles including various cyclopropane-, oxirane-, and aziridine-containing carbonitriles is summarized. On the basis of the outcomes of the biotransformation study, it is proposed that a readily reachable reactive site be embedded within the spacious pocket of the nitrile hydratase while the amidase might comprise a relatively deep-buried and size-limited active site. Applications of enantioselective biotransformations of nitriles in the synthesis of natural and bioactive products are also discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000280274000012 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70191]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang Meixiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Dexian,Wang Meixiang. Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis[J]. PROGRESS IN CHEMISTRY,2010,22(7):1397-1402. |
| APA | Wang Dexian,&Wang Meixiang.(2010).Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis.PROGRESS IN CHEMISTRY,22(7),1397-1402. |
| MLA | Wang Dexian,et al."Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis".PROGRESS IN CHEMISTRY 22.7(2010):1397-1402. |
入库方式： OAI收割
来源：化学研究所
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