Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry
文献类型：期刊论文
| 作者 | He Xiang-Wei1; Long Hai-Tao1; Yuan Gu1; Xu Xiao-Jie; Zhou Ya-Wei2 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 26期号:4页码:1082-1086 |
| 关键词 | Molecular Modeling Telomere G-quadruplex Dna Natural Product Molecule Electrospray Ionization Mass Spectrometry |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB20100416 |
| 英文摘要 | Electrospray ionization mass spectrometry (ESI-MS) was used to investigate the non-covalent interaction of human telomenc G-quadruplex (G4) DNA with 12 natural product molecules We found that Fangchinoline, a new ligand of the human telomenc G-quadruplex, had the highest binding affinity among these molecules The stabilities of the G-quadruplex and the complexes of the G-quadruplex with small molecules were investigated using a mass spectrometry heating experiment By Fangchinoline binding, the dissociation temperature (T-1/2) value of the complex of G-quadruplex with the ligand increased to 200 degrees C. We studied the binding mode and stability of the G-quadruplex with the small molecules using Autodock Possible binding sites were found and the binding energy was about -31 5 kJ mol Unlike the typical binding molecules with a planar structure. Fangchinoline is a new kind of G-quadruplex ligand and it gives us a different Insight for the design of new G-quadruplex ligands |
| 语种 | 英语 |
| WOS记录号 | WOS:000276958400036 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70297]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yuan Gu |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan & Mol Engn, Beijing Natl Lab Mol Sci,Educ Minist,Dept Chem Bi, Beijing 100871, Peoples R China 2.Peking Univ, Baschoior Res Ctr, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | He Xiang-Wei,Long Hai-Tao,Yuan Gu,et al. Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(4):1082-1086. |
| APA | He Xiang-Wei,Long Hai-Tao,Yuan Gu,Xu Xiao-Jie,&Zhou Ya-Wei.(2010).Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry.ACTA PHYSICO-CHIMICA SINICA,26(4),1082-1086. |
| MLA | He Xiang-Wei,et al."Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry".ACTA PHYSICO-CHIMICA SINICA 26.4(2010):1082-1086. |
入库方式： OAI收割
来源：化学研究所
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