Inhibition of Amyloid Fibrillization and Dissociation of Matured Amyloid Fibrils by Mj HSP16.5
文献类型：期刊论文
| 作者 | Cao Ao-Neng1,2; Wang Wei-Xue2; Yuwen Tai-Ran2; Deng Wei2; Lai Lu-Hua2 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 26期号:7页码:2015-2020 |
| 关键词 | Amyloid Fibril Inhibition Dissociation Small Heat Shock Protein Mj Hsp16.5 |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB20100708 |
| 英文摘要 | The amyloid fibrillization of proteins and peptides is related to many human diseases including Alzheimer's disease. Currently there is no effective therapy for these diseases, because the mechanism of the amyloid fibrillization is still not clear. Understanding how to effectively inhibit amyloid formation will shed light on the prevention and treatment of these diseases. Transtheritin (TTR) and its mutants easily form amyloid fibrils and are related to many diseases. Mj HSP16.5, a small heat shock protein (SHSP) from Methanococcus jannaschii shows high chaperone. like activity under acidic conditions, and these conditions promote the fibrillization of many peptides. We studied the influence of Mj HSP16.5 on the fibrillization of the peptide WTTR (sequence: WYTIAALLSPYS, i.e., the 105-115 fragment of TTR with a tryptophan added to its N-terminal). Mj HSP16.5 was found to significantly inhibit the growth and maturation of the WTTR fibrils resulting in much thinner fibrils compared to those under normal conditions. More interestingly, Mj SHSP16.5 can dissociate the matured WTTR fibrils. Based on our experimental results, a possible inhibition mechanism was proposed in which Mj SHP16.5 interacted with WTTR fibrils and/or seeds. |
| 语种 | 英语 |
| WOS记录号 | WOS:000279776400040 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70415]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Cao Ao-Neng |
| 作者单位 | 1.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao Ao-Neng,Wang Wei-Xue,Yuwen Tai-Ran,et al. Inhibition of Amyloid Fibrillization and Dissociation of Matured Amyloid Fibrils by Mj HSP16.5[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(7):2015-2020. |
| APA | Cao Ao-Neng,Wang Wei-Xue,Yuwen Tai-Ran,Deng Wei,&Lai Lu-Hua.(2010).Inhibition of Amyloid Fibrillization and Dissociation of Matured Amyloid Fibrils by Mj HSP16.5.ACTA PHYSICO-CHIMICA SINICA,26(7),2015-2020. |
| MLA | Cao Ao-Neng,et al."Inhibition of Amyloid Fibrillization and Dissociation of Matured Amyloid Fibrils by Mj HSP16.5".ACTA PHYSICO-CHIMICA SINICA 26.7(2010):2015-2020. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。