Application of the Biodegradable Diblock Copolymer Poly(L-lactide)-block-Poly(L-cysteine): Drug Delivery and Protein Conjugation
文献类型：期刊论文
| 作者 | Sun, Jing1,2; Chen, Xuesi1; Wei, Jizheng1,2; Yan, Lesan1,2; Jing, Xiabin1 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2010-11-05 |
| 卷号 | 118期号:3页码:1738-1742 |
| 关键词 | Block Copolymers Crosslinking Self-assembly |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.32341 |
| 英文摘要 | A novel approach to self-assembled and shell-crosslinked (SCL) micelles from the diblock copolymer poly(L-lactide)-block-poly(L-cysteine) to be used as drug and protein delivery carriers is described. Rifampicin was used as a model drug. The drug-loaded SCL micelles were obtained by self-assembly of the copolymer in the presence of the drug in aqueous media. Their morphology and size were studied with dynamic light scattering and field emission scanning electron microscopy. The rifampicin loading capacity and encapsulation efficiency were studied with ultraviolet visible spectrophotometry. The drug-release rate in vitro depended on the oxidizing and reducing environment. Moreover, a straightforward approach to the conjugation of the copolymer with bovine serum albumin (BSA) was developed, and a gel electrophoresis test demonstrated that this conjugated BSA could be reversibly released from the copolymer substrate under reducing conditions. In conclusion, this L-cysteine copolymer can be used in drug delivery and in protein fixation and recovery. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 1738-1742, 2010 |
| 语种 | 英语 |
| WOS记录号 | WOS:000281448900062 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70425]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jing,Chen, Xuesi,Wei, Jizheng,et al. Application of the Biodegradable Diblock Copolymer Poly(L-lactide)-block-Poly(L-cysteine): Drug Delivery and Protein Conjugation[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2010,118(3):1738-1742. |
| APA | Sun, Jing,Chen, Xuesi,Wei, Jizheng,Yan, Lesan,&Jing, Xiabin.(2010).Application of the Biodegradable Diblock Copolymer Poly(L-lactide)-block-Poly(L-cysteine): Drug Delivery and Protein Conjugation.JOURNAL OF APPLIED POLYMER SCIENCE,118(3),1738-1742. |
| MLA | Sun, Jing,et al."Application of the Biodegradable Diblock Copolymer Poly(L-lactide)-block-Poly(L-cysteine): Drug Delivery and Protein Conjugation".JOURNAL OF APPLIED POLYMER SCIENCE 118.3(2010):1738-1742. |
入库方式： OAI收割
来源：化学研究所
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