SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES
文献类型：期刊论文
| 作者 | Sun Peijian1,2; Shi Xudong1; Gan Zhihua1 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2010-04-20 |
| 期号 | 4页码:383-389 |
| 关键词 | Raft Poly(N-isopropylacyamide) Terpyridine Thermo-sensitive Therapeutic Isotopes |
| ISSN号 | 1000-3304 |
| 英文摘要 | A new terpyridine-functionalized dithioester was synthesized as a chain transfer agent in the reversible addition fragmentation chain transfer polymerization (RAFT) of N-isopropylacyamide (NIPAAm). The polymerization showed an first-order kinetics and the molecular weight increased linearly with conversion, indicating that the terpyridine-functionalized dithioester is an efficient chain transfer agent for the RAFT polymerization of NIPAAm. The terpyridine-functionalized poly (N-isopropylacyamide) (tpy-PNIPAAm) not only displays similar phase transition as PNIPAAm, but also have the coordination ability via terpyridine, which were further used to construct macromolecular-metal complex with ferrous ions as model metal ions. The appearance of a strong absorption at 555 nm in UV-Vis spectrum revealed the formation of macromolecular-metal complex, indicating the strong coordination ability of tpy-PNIPAAm to metal. Cloud point method and dynamic light scattering (DLS) were used to characterize the thermosensitivity of tpy-PNIPAAm and macromolecular-metal complex. The results showed that the macromolecular-metal complex could self-assemble into nanoparticles in aqueous solution due to the amphiphilic property The macromolecular-metal complex solution showed a similar phase transition as PNIPAAm. In addition, the nanoparticles of the macromolecular-metal complex in aqueous solution were stable even at temperature above the lower critical solution temperature (LCST) due to electrostatic repulsion. This work indicated the great potentials of tpy-PNIPAAm as carriers for the delivery of therapeutic radioisotopes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000277591700001 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70581]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sun Peijian |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun Peijian,Shi Xudong,Gan Zhihua. SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES[J]. ACTA POLYMERICA SINICA,2010(4):383-389. |
| APA | Sun Peijian,Shi Xudong,&Gan Zhihua.(2010).SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES.ACTA POLYMERICA SINICA(4),383-389. |
| MLA | Sun Peijian,et al."SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES".ACTA POLYMERICA SINICA .4(2010):383-389. |
入库方式： OAI收割
来源：化学研究所
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