Local site preference rationalizes disentangling by DNA topoisomerases
文献类型：期刊论文
| 作者 | Liu, Zhirong1,2; Zechiedrich, Lynn3,4; Chan, Hue Sun5,6,7 |
| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2010-03-01 |
| 卷号 | 81期号:3 |
| ISSN号 | 1539-3755 |
| DOI | 10.1103/PhysRevE.81.031902 |
| 英文摘要 | To rationalize the disentangling action of type II topoisomerases, an improved wormlike DNA model was used to delineate the degree of unknotting and decatenating achievable by selective segment passage at specific juxtaposition geometries and to determine how these activities were affected by DNA circle size and solution ionic strength. We found that segment passage at hooked geometries can reduce knot populations as dramatically as seen in experiments. Selective segment passage also provided theoretical underpinning for an intriguing empirical scaling relation between unknotting and decatenating potentials. |
| 语种 | 英语 |
| 出版者 | AMER PHYSICAL SOC |
| WOS记录号 | WOS:000276199300085 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70677]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Zhirong |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Ctr Theoret Biol, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 3.Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Dept Mol Virol & Microbiol, Houston, TX 77030 USA 4.Baylor Coll Med, Dept Pharmacol, Houston, TX 77030 USA 5.Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada 6.Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada 7.Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada |
| 推荐引用方式 GB/T 7714 | Liu, Zhirong,Zechiedrich, Lynn,Chan, Hue Sun. Local site preference rationalizes disentangling by DNA topoisomerases[J]. PHYSICAL REVIEW E,2010,81(3). |
| APA | Liu, Zhirong,Zechiedrich, Lynn,&Chan, Hue Sun.(2010).Local site preference rationalizes disentangling by DNA topoisomerases.PHYSICAL REVIEW E,81(3). |
| MLA | Liu, Zhirong,et al."Local site preference rationalizes disentangling by DNA topoisomerases".PHYSICAL REVIEW E 81.3(2010). |
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来源：化学研究所
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