Lactose mediated liver-targeting effect observed by ex vivo imaging technology
文献类型：期刊论文
| 作者 | Ma, Ping'an2; Liu, Shi1; Huang, Yubin1; Chen, Xuesi1; Zhang, Liping2; Jing, Xiabin1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2010-03-01 |
| 卷号 | 31期号:9页码:2646-2654 |
| 关键词 | Ex Vivo Imaging Lactose Liver-targeting Mixed Micelles Rhodamine b |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2009.12.019 |
| 英文摘要 | Two kinds of micelles containing Rhodamine B were prepared by a solvent evaporation method One (Lac-f-micelles lactose-free micelles) was from a Rhodamine-containing copolymer, poly(ethylene glycol)-b-poly(L-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) [PEC(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine)], and the other (Lac | micelles lactose-containing micelles) was from a mixture of the targeting copolymer lactose-poly(ethylene glycol)-poly (L-Lactide) [Lac-PEG(4600)-PLA(4500)] and the Rhodamine-containing copolymer PEG(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine) ESEM and DLS measurements showed that the two kinds of micelles have similar size (in the range of 60-100 nm) and size distribution Cellular uptake Studies in vitro revealed that the Lac+micelles showed stronger endocytosis ability than Lac-f-micelles in SMMC7221 human liver cancer cells, but the Lac+micelles were rarely internalized by Vero cells The micelle solutions were administrated into mice via tail intravenous injection. Then, five visceral organs were isolated from the mice at specified time intervals and relative fluorescent intensities of the ex vivo organs and their homogenates were examined by CRI Maestro 500FL in vivo imaging system The results showed that the Lac+micelles showed more remarkable liver-targeting effect than the Lac-f-micelles And the liver-targeting effect Could be established in ca 12 h after tail i v injection (C) 2009 Elsevier Ltd All rights reserved |
| 语种 | 英语 |
| WOS记录号 | WOS:000275348800022 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70821]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Ping'an,Liu, Shi,Huang, Yubin,et al. Lactose mediated liver-targeting effect observed by ex vivo imaging technology[J]. BIOMATERIALS,2010,31(9):2646-2654. |
| APA | Ma, Ping'an,Liu, Shi,Huang, Yubin,Chen, Xuesi,Zhang, Liping,&Jing, Xiabin.(2010).Lactose mediated liver-targeting effect observed by ex vivo imaging technology.BIOMATERIALS,31(9),2646-2654. |
| MLA | Ma, Ping'an,et al."Lactose mediated liver-targeting effect observed by ex vivo imaging technology".BIOMATERIALS 31.9(2010):2646-2654. |
入库方式： OAI收割
来源：化学研究所
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