Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent
文献类型：期刊论文
| 作者 | Zheng, Li1,2,5; Gu, Zhanjun3; Ma, Ying2; Zhang, Guangjin1; Yao, Jiannian2; Keita, Bineta4; Nadjo, Louis4 |
| 刊名 | JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 15期号:7页码:1079-1085 |
| 关键词 | Lanthanide Polyoxometalates Histone H1 Luminescence Fluorescence Molecular Interaction Biolabel |
| ISSN号 | 0949-8257 |
| DOI | 10.1007/s00775-010-0667-5 |
| 英文摘要 | Polyoxometalates (POMs) show promising biological activities, but the mechanism of potential therapeutic effects remains to be elucidated at a molecular level. As a step toward the elucidation of the mechanistic pathways governing the bioactivity of POMs, the interaction between Eu-containing decatungstate [EuW(10)O(36)](9-) (EuW10) and histone H1 has been studied. Fluorescence/luminescence analysis showed the existence of a strong interaction between EuW10 and histone H1. This interaction has key effects both on the luminescence of EuW10 and on the structure of histone H1. A gradual and intense enhancement of EuW10 luminescence was observed upon addition of increasing concentrations of histone H1. Circular dichroism investigations indicated that the binding of EuW10 significantly alters the secondary structure of histone H1. The present work is meaningful in finding novel labeling agents for fluorescence/luminescence or solid-state bioimaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000281597900009 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70825]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Guangjin |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Green Proc Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China 4.Univ Paris 11, Chim Phys Lab, CNRS, UMR 8000, F-91405 Orsay, France 5.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Li,Gu, Zhanjun,Ma, Ying,et al. Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2010,15(7):1079-1085. |
| APA | Zheng, Li.,Gu, Zhanjun.,Ma, Ying.,Zhang, Guangjin.,Yao, Jiannian.,...&Nadjo, Louis.(2010).Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,15(7),1079-1085. |
| MLA | Zheng, Li,et al."Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 15.7(2010):1079-1085. |
入库方式： OAI收割
来源：化学研究所
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