Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase
文献类型：期刊论文
| 作者 | Cui, Yi1; Jiao, Zhaodong1; Gong, Jianxian1; Yu, Quan2; Zheng, Xiaofeng2; Quan, Junmin1; Luo, Ming1,3,4; Yang, Zhen1,5,6,7 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 12期号:1页码:4-7 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol902438f |
| 英文摘要 | A concise and modular approach to synthesize a new type of cyclopentene-based diaminocyclitol library from D-serine and L-serine has been developed, and key steps in this synthesis are an aza-Claisen rearrangement, a ring-closing metathesis, and a Baylis-Hillman reaction. The developed chemistry may offer a unique way to Investigate the neuraminidase (NA) mutation by systematically mapping the changes within its binding sites. |
| 语种 | 英语 |
| WOS记录号 | WOS:000272937200002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/70883]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Quan, Junmin |
| 作者单位 | 1.Peking Univ, Lab Chem Genom, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China 2.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China 3.Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA 4.Univ Alabama, Ctr Biophys Sci & Engn, Birmingham, AL 35294 USA 5.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China 6.Peking Univ, BNLMS, Coll Chem, Beijing 100871, Peoples R China 7.Peking Univ, State Key Lab, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Yi,Jiao, Zhaodong,Gong, Jianxian,et al. Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase[J]. ORGANIC LETTERS,2010,12(1):4-7. |
| APA | Cui, Yi.,Jiao, Zhaodong.,Gong, Jianxian.,Yu, Quan.,Zheng, Xiaofeng.,...&Yang, Zhen.(2010).Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase.ORGANIC LETTERS,12(1),4-7. |
| MLA | Cui, Yi,et al."Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase".ORGANIC LETTERS 12.1(2010):4-7. |
入库方式： OAI收割
来源：化学研究所
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