Tumor angiogenesis imaging agent: biodistribution of I-131-YG5 and I-131-Boc-YG5
文献类型：期刊论文
| 作者 | Sun Xin; Chu Taiwei; Wang Xiangyun |
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2010-10-20 |
| 卷号 | 21期号:5页码:302-305 |
| ISSN号 | 1001-8042 |
| 关键词 | Radioiodination Angiogenesis Biodistribution Ngr Deiodination T-butyloxycarbonyl |
| 英文摘要 | The cyclic peptide YG5 and the t-butyloxycarbonyl (Boc)-modified analog (Boc-YG5) were labeled with radioiodine. The radiochemical purity of I-131-YG5 or I-131-Boc-YG5 was almost 100% after purification by RP-HPLC. Biodistribution in BALB/C nude mice bearing MCF-7 tumor was measured. After t-butyloxycarbonyl (Boc)-modification, the I-131-Boc-YG5 was quite resistant to deiodination in vivo, resulting in negligible radioactivity accumulation in thyroid. The radiotracer clearance in tumor became faster, the absolute tumor uptake decreased for I-131-Boc-YG5, but the tumor-to-tissue uptake ratios increased. The uptake ratios of tumor to muscle, blood, heart, and lung at I h post injection reached 4.73, 1.70, 4.09 and 1.70, respectively. It is demonstrated that Boc-group is an effective prosthetic one to prevent deiodination in vivo and improve tumor imaging for radioiodinated NGR. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000285989600010 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71035]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chu Taiwei |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Radiochem & Radiat Chem Key Lab Fundamental Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun Xin,Chu Taiwei,Wang Xiangyun. Tumor angiogenesis imaging agent: biodistribution of I-131-YG5 and I-131-Boc-YG5[J]. NUCLEAR SCIENCE AND TECHNIQUES,2010,21(5):302-305. |
| APA | Sun Xin,Chu Taiwei,&Wang Xiangyun.(2010).Tumor angiogenesis imaging agent: biodistribution of I-131-YG5 and I-131-Boc-YG5.NUCLEAR SCIENCE AND TECHNIQUES,21(5),302-305. |
| MLA | Sun Xin,et al."Tumor angiogenesis imaging agent: biodistribution of I-131-YG5 and I-131-Boc-YG5".NUCLEAR SCIENCE AND TECHNIQUES 21.5(2010):302-305. |
入库方式： OAI收割
来源：化学研究所
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