Conjugated Polymer Nanoparticles for Drug Delivery and Imaging
文献类型：期刊论文
| 作者 | Feng, Xuli; Lv, Fengting; Liu, Libing; Tang, Hongwei; Xing, Chengfen; Yang, Qiong; Wang, Shu |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 2期号:8页码:2429-2435 |
| 关键词 | Conjugated Polymers Nanoparticles Imaging Drug Delivery |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am100435k |
| 英文摘要 | We prepared a new conjugated polymer nanoparticle with the size of about 50 nm that is prepared by electrostatic assembly of cationic conjugated polymer PFO and anionic poly(L-glutamic acid) conjugated with anticancer drug doxorubicin (PFO/PG-Dox). The PFO exhibits good fluorescence quantum yield, photostability, and little cytotoxicity to meet the essential requests for cell imaging. In PFO/PG-Dox nanoparticles, the fluorescence of PFO is highly quenched by Dox by electron transfer mechanism, and thus the PFO is in the fluorescence "turn-off" state. After PFO/PG-Dox nanoparticles are exposed to carboxypeptidase or are taken up by cancer cells, the poly(L-glutamic acid) is hydrolysed to release the Dox, inducing the activation of PFO fluorescence to "turn-on" state. This multifunctional nanoparticle system can deliver Dox to targeted cancer cells and monitor the Dox release based on fluorescence "turn-on" signal of PFO, which concurrently images the cancer cells. The present work opens the door for new functional studies of conjugated polymer in simultaneous imaging and disease therapeutics. |
| 语种 | 英语 |
| WOS记录号 | WOS:000281109300039 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71123]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Libing |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Xuli,Lv, Fengting,Liu, Libing,et al. Conjugated Polymer Nanoparticles for Drug Delivery and Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2010,2(8):2429-2435. |
| APA | Feng, Xuli.,Lv, Fengting.,Liu, Libing.,Tang, Hongwei.,Xing, Chengfen.,...&Wang, Shu.(2010).Conjugated Polymer Nanoparticles for Drug Delivery and Imaging.ACS APPLIED MATERIALS & INTERFACES,2(8),2429-2435. |
| MLA | Feng, Xuli,et al."Conjugated Polymer Nanoparticles for Drug Delivery and Imaging".ACS APPLIED MATERIALS & INTERFACES 2.8(2010):2429-2435. |
入库方式： OAI收割
来源：化学研究所
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