Multifunctional Conjugates To Prepare Nucleolar-Targeting CdS Quantum Dots
文献类型：期刊论文
| 作者 | Shen, Ran1; Shen, Xiaoqin1; Zhang, Zengming2; Li, Yuesheng3; Liu, Shiyong1; Liu, Hewen1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2010-06-30 |
| 卷号 | 132期号:25页码:8627-8634 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja1002668 |
| 英文摘要 | We used a click reaction to synthesize a bidentate 1,2,3-triazole-based ligand, TA, for use in the preparation of aqueous CdS quantum dots (QDs). TA-conjugated CdS QDs exhibited two fluorescence emission peaks, one at 540 nm arising from CdS nanocrystals and the other at similar to 670 nm arising from TA-CdS OD complexes formed via surface coordination. Coordination between TA and CdS was verified by using X-ray photoelectron (N 1s) spectra as well as Raman and NMR spectra of TA-capped QDs. Electrochemical analysis revealed that the 1,2,3-triazole moities in TA form complexes with the Cd(II) ions. The aqueous QDs protected by TA were very stable at different ionic strengths and over a broad pH range, according to fluorescence analysis. The ethidium bromide exclusion assay demonstrated that the bidentate TA ligand interacts strongly with DNA. Fluorescent micrographs and TEM images of cancer cells stained with TA-capped QDs clearly showed that the TA ligand targeted CdS QDs to the nucleoli of cells. In contrast, thioglycolic acid-capped CdS ODs just stained the cell membranes and could not pass the cell membranes to reach the cell nucleus. |
| 语种 | 英语 |
| WOS记录号 | WOS:000279196500027 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71157]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Hewen |
| 作者单位 | 1.Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Astron & Appl Phys, Hefei 230026, Anhui, Peoples R China 3.Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Ran,Shen, Xiaoqin,Zhang, Zengming,et al. Multifunctional Conjugates To Prepare Nucleolar-Targeting CdS Quantum Dots[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010,132(25):8627-8634. |
| APA | Shen, Ran,Shen, Xiaoqin,Zhang, Zengming,Li, Yuesheng,Liu, Shiyong,&Liu, Hewen.(2010).Multifunctional Conjugates To Prepare Nucleolar-Targeting CdS Quantum Dots.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,132(25),8627-8634. |
| MLA | Shen, Ran,et al."Multifunctional Conjugates To Prepare Nucleolar-Targeting CdS Quantum Dots".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132.25(2010):8627-8634. |
入库方式： OAI收割
来源：化学研究所
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