Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers
文献类型：期刊论文
| 作者 | Hong, Youliang1; Chen, Xuesi2; Jing, Xiabin2; Fan, Hongsong1; Gu, Zhongwei1; Zhang, Xingdong1 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2010-05-10 |
| 卷号 | 20期号:9页码:1503-1510 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.200901627 |
| 英文摘要 | Ultrathin mesoporous bioactive glass hollow fibers (MBGHFs) fabricated using an electrospinning technique and combined with a phase-separaiion-induced agent, poly(ethylene oxide) (PEO), are described. The rapid solvent evaporation during electrospinning and the PEO-induced phase separation process demonstrated play vital roles in the formation of ultrathin bioactive glass fibers with hollow cores and mesoporous walls. Immersing the MBGHFs in simulated body fluid rapidly results in the development of a layer of enamel-like apatite mesocrystals at the fiber surfaces and apatite nanocrystals inside the hollow cores. Drug loading and release experiments indicate that the drug loading capacity and drug release behavior of the MBGHFs strongly depends on the fiber length. MBGHFs with fiber length >50 mu m can become excellent carriers for drug delivery. The shortening of the fiber length reduces drug loading amounts and accelerates drug release. The MBGHFs reported here with sophisticated structure, high bioactivity, and good drug delivery capability can be a promising scaffold for hard tissue repair and wound healing when organized into 3D macroporous membranes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000277806000019 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71171]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Hong, Youliang |
| 作者单位 | 1.Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Youliang,Chen, Xuesi,Jing, Xiabin,et al. Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers[J]. ADVANCED FUNCTIONAL MATERIALS,2010,20(9):1503-1510. |
| APA | Hong, Youliang,Chen, Xuesi,Jing, Xiabin,Fan, Hongsong,Gu, Zhongwei,&Zhang, Xingdong.(2010).Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers.ADVANCED FUNCTIONAL MATERIALS,20(9),1503-1510. |
| MLA | Hong, Youliang,et al."Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers".ADVANCED FUNCTIONAL MATERIALS 20.9(2010):1503-1510. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。