Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA
文献类型：期刊论文
| 作者 | Tian, Mingyue1; Zhang, Xiufeng2; Li, Yan3; Ju, Yong3; Xiang, Junfeng2; Zhao, Changqi1; Tang, Yalin2 |
| 刊名 | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
 |
| 出版日期 | 2010 |
| 卷号 | 29期号:3页码:190-199 |
| 关键词 | C-myc Gene G-quadruplexes Bile Acid-amino Acid Conjugate Down-regulation Of Transcription |
| ISSN号 | 1525-7770 |
| DOI | 10.1080/15257771003704875 |
| 英文摘要 | Human c-myc gene is a central regulator of cellular proliferation and cell growth, and G-quadruplexes have been proven to be the transcriptional controller of this gene. In this study, the interaction of bile acid-amino acid conjugate (BAA) with G-quadruplexes in c-myc was investigated by circular dichroism spectroscopy, nuclear magnetic resonance (NMR) measurement, and quantitative real-time polymerase chain reaction (PCR) assay. The experimental results indicated that BAA has the ability to selectively induce the formation of parallel G-quadruplexes in c-myc, which leads to down-regulation of c-myc transcription in the human breast cancer cell MCF-7. |
| 语种 | 英语 |
| WOS记录号 | WOS:000277621100004 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71185]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Changqi |
| 作者单位 | 1.Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Engn Drugs & Biol Technol, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 3.Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Mingyue,Zhang, Xiufeng,Li, Yan,et al. Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA[J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS,2010,29(3):190-199. |
| APA | Tian, Mingyue.,Zhang, Xiufeng.,Li, Yan.,Ju, Yong.,Xiang, Junfeng.,...&Tang, Yalin.(2010).Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA.NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS,29(3),190-199. |
| MLA | Tian, Mingyue,et al."Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA".NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 29.3(2010):190-199. |
入库方式： OAI收割
来源：化学研究所
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