Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]
文献类型：期刊论文
| 作者 | Zhang, Rui1; Wang, Yang1; Du, Fu-Sheng1; Wang, Ying-Li2; Tan, Ying-Xia2; Ji, Shou-Ping2; Li, Zi-Chen1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2011-10-10 |
| 卷号 | 11期号:10页码:1393-1406 |
| 关键词 | Cationic Gene Carriers Hyperthermia Polyethylenimine Poly[Oligo(Ethylene Glycol) Methacrylate] Thermoresponsive |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201100094 |
| 英文摘要 | A family of thermoresponsive cationic copolymers (TCPs) that contain branched PEI 25 K as the cationic segment and poly(MEO(2)MA-co-OEGMA(475)) as the thermosensitive block (TP) is prepared. The DNA binding capability, physicochemical properties, and biological performance of the TCPs are studied. All of these TCPs can condense DNA to form polyplexes with diameters of 150-300nm and zeta potentials of 7-32mV at N/P ratios between 12 and 36. The length of TP block is a key factor for shielding the positive surface charge of the polyplexes and protecting them against protein adsorption. TCPs with a higher TP content have a lower cytotoxicity while the best transfection performance is achieved by the TCPs with longest TP length, reaching a level of the intact PEI 25 K in the presence of serum. |
| 语种 | 英语 |
| WOS记录号 | WOS:000296138500012 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71465]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Du, Fu-Sheng |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Beijing Inst Transfus Med, Dept Mol Biol, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rui,Wang, Yang,Du, Fu-Sheng,et al. Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate][J]. MACROMOLECULAR BIOSCIENCE,2011,11(10):1393-1406. |
| APA | Zhang, Rui.,Wang, Yang.,Du, Fu-Sheng.,Wang, Ying-Li.,Tan, Ying-Xia.,...&Li, Zi-Chen.(2011).Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate].MACROMOLECULAR BIOSCIENCE,11(10),1393-1406. |
| MLA | Zhang, Rui,et al."Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]".MACROMOLECULAR BIOSCIENCE 11.10(2011):1393-1406. |
入库方式： OAI收割
来源：化学研究所
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