Single-molecule imaging revealed enhanced dimerization of transforming growth factor beta type II receptors in hypertrophic cardiomyocytes
文献类型：期刊论文
| 作者 | He, Kangmin1,2,3; Fu, Yongnan2,3; Zhang, Wei1; Yuan, Jinghe1; Li, Zijian2,3; Lv, Zhizhen2,3; Zhang, Youyi2,3; Fang, Xiaohong1 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2011-04-08 |
| 卷号 | 407期号:2页码:313-317 |
| 关键词 | Transforming Growth Factor Beta Type Ii Receptors Angiotensin Ii Phenylephrine Hypertrophic Cardiomyocyte Single Molecule Imaging |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2011.03.008 |
| 英文摘要 | Transforming growth factor beta (TGF-beta) signaling plays an important role in the pathogenesis of cardiac hypertrophy. However, the molecular mechanism of TGF-beta signaling during the process of cardiac remodeling remains poorly understood. In the present study, by employing single-molecule fluorescence imaging approach, we demonstrated that in neonatal rat cardiomyocytes. TGF-beta type II receptors (T beta RII) existed as monomers at the low expression level, and dimerized upon TGF-beta 1 stimulation. Importantly, for the first time, we found the increased dimerization of T beta RII in hypertrophic cardiomyocytes comparing to the normal cardiomyocytes. The enhanced T beta RII dimerization was correlated with the enhanced Smad3 phosphorylation levels. These results provide new information on the mechanism of TGF-beta signaling in cardiac remodeling. (C) 2011 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000289746700008 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71663]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Youyi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Peking Univ, Inst Vasc Med, Hosp 3, Minist Educ,Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China 3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Kangmin,Fu, Yongnan,Zhang, Wei,et al. Single-molecule imaging revealed enhanced dimerization of transforming growth factor beta type II receptors in hypertrophic cardiomyocytes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,407(2):313-317. |
| APA | He, Kangmin.,Fu, Yongnan.,Zhang, Wei.,Yuan, Jinghe.,Li, Zijian.,...&Fang, Xiaohong.(2011).Single-molecule imaging revealed enhanced dimerization of transforming growth factor beta type II receptors in hypertrophic cardiomyocytes.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,407(2),313-317. |
| MLA | He, Kangmin,et al."Single-molecule imaging revealed enhanced dimerization of transforming growth factor beta type II receptors in hypertrophic cardiomyocytes".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407.2(2011):313-317. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。