Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds
文献类型：期刊论文
| 作者 | Du, Mingchun1; Song, Weixing2; Cui, Yue1; Yang, Yang2; Li, Junbai1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:7页码:2228-2236 |
| ISSN号 | 0959-9428 |
| DOI | 10.1039/c0jm02869j |
| 英文摘要 | We have fabricated tubular hydrogel scaffolds of nano-hydroxyapatite (nHA)/alginate (ALG) via a layer-by-layer (LbL) technique. Using Ca2+ as a crosslinker, nHA was assembled with ALG to form a hydrogel network. The inner diameter of scaffolds could be controlled from 0.5 mm to 7 mm by varying the assembled layer numbers of nHA/ALG pairs. By changing the nHA concentration, we can also control the crosslinking degree of the hydrogel network, and further change the mechanical properties, swelling behavior, permeability and diffusivity of the scaffolds. The elastic modulus of the hydrogel scaffolds was regulated from 0.98 +/- 0.05 MPa to 2.78 +/- 0.08 MPa as the concentration of nHA was changed from 50 mg mL(-1) to 300 mg mL(-1), which reached the requirements of avascular soft tissue. The diffusion coefficient was tuned from 23.84 x 10(-7) cm(2) s(-1) to 9.92 x 10(-7) cm(2) s(-1) for controlled mass transport in the hydrogel network. Moreover, human embryo skin fibroblast (ESF) culture experiments prove that nHA can improve cellular adhesion on the hydrogel surface. These results thus suggest that the assembled nHA/ALG hydrogel scaffolds are an attractive biomaterial for great potential application in soft tissue engineering. |
| 语种 | 英语 |
| WOS记录号 | WOS:000286834600032 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71675]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS,Int Joint Lab, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Mingchun,Song, Weixing,Cui, Yue,et al. Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(7):2228-2236. |
| APA | Du, Mingchun,Song, Weixing,Cui, Yue,Yang, Yang,&Li, Junbai.(2011).Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds.JOURNAL OF MATERIALS CHEMISTRY,21(7),2228-2236. |
| MLA | Du, Mingchun,et al."Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds".JOURNAL OF MATERIALS CHEMISTRY 21.7(2011):2228-2236. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。