One-Pot Selective Syntheses of 5-Azaindoles through Zirconocene-Mediated Multicomponent Reactions with Three Different Nitrile Components and One Alkyne Component
文献类型：期刊论文
| 作者 | Zhang, Shaoguang1; Zhang, Wen-Xiong1; Zhao, Jing2; Xi, Zhenfeng1,3 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 17期号:8页码:2442-2449 |
| 关键词 | 5-azaindoles Multicomponent Reactions Nitriles Nitrogen Heterocycles Zirconium |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201003119 |
| 英文摘要 | 5-Azaindoles either with three different substituents at their 2-, 4-, and 6-positions or with two identical substituents at their 2- and 6-positions and a different one at the 4-position, were obtained in good to excellent isolated yields by a zirconocene-mediated multicomponent process. Each reaction involved four organic partners, comprising a Si-tethered diyne, one tBuCN component, and two (either different or identical) nitriles. All these four components were combined through the action of a Cp2ZrII species into a three-ring fused Zr/Si-containing organometallic complex in a perfectly chemo-and regioselective manner. This multicomponent reaction process consisted of three reaction steps, all of which were made clear through the isolation and characterization of their cor-responding organometallic intermediates: the zirconacyclopropene-azasila-cyclopentadienes 2, the allenyl-aza-zirconacycles 3, and the three-ring fused complexes 6. X-ray single-crystal structural analyses of two three-ring fused Zr/Si-containing intermediates and two 5-azaindoles unambiguously showed the positions of the different substituents and the regioselectivity. Iminopyrrole derivatives could be also highly selectively prepared from a Si-tethered diyne and two different nitriles. |
| 语种 | 英语 |
| WOS记录号 | WOS:000288096800021 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71745]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xi, Zhenfeng |
| 作者单位 | 1.Peking Univ, Coll Chem, Minist Educ,Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.CAS, Inst Chem, Beijing 100190, Peoples R China 3.Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shaoguang,Zhang, Wen-Xiong,Zhao, Jing,et al. One-Pot Selective Syntheses of 5-Azaindoles through Zirconocene-Mediated Multicomponent Reactions with Three Different Nitrile Components and One Alkyne Component[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(8):2442-2449. |
| APA | Zhang, Shaoguang,Zhang, Wen-Xiong,Zhao, Jing,&Xi, Zhenfeng.(2011).One-Pot Selective Syntheses of 5-Azaindoles through Zirconocene-Mediated Multicomponent Reactions with Three Different Nitrile Components and One Alkyne Component.CHEMISTRY-A EUROPEAN JOURNAL,17(8),2442-2449. |
| MLA | Zhang, Shaoguang,et al."One-Pot Selective Syntheses of 5-Azaindoles through Zirconocene-Mediated Multicomponent Reactions with Three Different Nitrile Components and One Alkyne Component".CHEMISTRY-A EUROPEAN JOURNAL 17.8(2011):2442-2449. |
入库方式： OAI收割
来源：化学研究所
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