Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers
文献类型：期刊论文
| 作者 | Li, Taihang2,3; Han, Ruiyan2; Wang, Mingzhe2; Liu, Changbai1; Jing, Xiabin2; Huang, Yubin2 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2011-11-10 |
| 卷号 | 11期号:11页码:1570-1578 |
| 关键词 | Biodegradable Block Copolymers Fusiform Micelles Self-assembly |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201100147 |
| 英文摘要 | PEG-PLA copolymers with dumbbell-and Y-shaped structures are prepared. They can self-assemble from nanoparticles to micro-sized fusiform micellar particles in aqueous solution. In particular the micelles formed by the (PLA)(2)-PEG-(PLA)(2) particles show a better drug loading capacity and encapsulation efficiency than those formed by linear MPEG-PLA. In vitro studies show that the particles formed by Y-shaped copolymers show a particularly quick drug release. The copolymers have good biocompatibility with low cytotoxicity. These unique self-assembled systems thus have many possible biomedical applications, such as a sustained delivery of high-dosed water insoluble drugs, quick effective drugs for trauma, controlled delivery of the oral-administration drugs, and so forth. |
| 语种 | 英语 |
| WOS记录号 | WOS:000297555500015 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71765]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Changbai |
| 作者单位 | 1.Three Georges Univ, Inst Mol Biol, Yichang 443002, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Taihang,Han, Ruiyan,Wang, Mingzhe,et al. Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers[J]. MACROMOLECULAR BIOSCIENCE,2011,11(11):1570-1578. |
| APA | Li, Taihang,Han, Ruiyan,Wang, Mingzhe,Liu, Changbai,Jing, Xiabin,&Huang, Yubin.(2011).Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers.MACROMOLECULAR BIOSCIENCE,11(11),1570-1578. |
| MLA | Li, Taihang,et al."Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers".MACROMOLECULAR BIOSCIENCE 11.11(2011):1570-1578. |
入库方式： OAI收割
来源：化学研究所
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