Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers
文献类型：期刊论文
| 作者 | Zhu, Yingdan; Sheng, Ruilong; Luo, Ting; Li, Hui; Sun, Wenyan; Li, Yang; Cao, Amin |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2011-02-11 |
| 卷号 | 11期号:2页码:174-186 |
| 关键词 | Amphiphiles Biocompatibility Biological Applications Of Polymers Drug Delivery Systems Synthesis |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201000225 |
| 英文摘要 | A new series of triblock [dendritic poly(L-lysine)]-block-PLLA-block-[dendritic poly(L-lysine)]s(DL(2)-PLLA-DL(2)) with PLLA block lengths of 11.5-26.5 and double 2-generation PLL dendrons DL(2) as model cationic amphiphiles were synthesized and characterized. Their CAC, self-aggregation and plasmid DNA binding affinities in pure water and PBS were studied. The PLLA block length dependence of particle size, morphology and xi potential for organized pDNA/amphiphile polyplex aggregates were examined. Finally, toxicities of these DL(2)-PLLA-DL(2) amphiphiles and their polyplexes were assayed by MTT with HeLa, SMMC-7721 and COS-7 cells, and COS-7 cell luciferase and eGFP gene transfection efficacies with these amphiphiles as the delivery carriers were investigated. |
| 语种 | 英语 |
| WOS记录号 | WOS:000287162800002 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71783]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Cao, Amin |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Organ Chem, Polymer Mat Lab, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Yingdan,Sheng, Ruilong,Luo, Ting,et al. Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers[J]. MACROMOLECULAR BIOSCIENCE,2011,11(2):174-186. |
| APA | Zhu, Yingdan.,Sheng, Ruilong.,Luo, Ting.,Li, Hui.,Sun, Wenyan.,...&Cao, Amin.(2011).Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers.MACROMOLECULAR BIOSCIENCE,11(2),174-186. |
| MLA | Zhu, Yingdan,et al."Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers".MACROMOLECULAR BIOSCIENCE 11.2(2011):174-186. |
入库方式： OAI收割
来源：化学研究所
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