Biodegradable Polymer Microcapsules Fabrication through a Template-Free Approach
文献类型：期刊论文
| 作者 | Yu, Xi1,2; Zhao, Ziliang3; Nie, Wei3; Deng, Renhua1,2; Liu, Shanqin1,2; Liang, Ruijing1,2; Zhu, Jintao1,2; Ji, Xiangling3 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2011-08-16 |
| 卷号 | 27期号:16页码:10265-10273 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/la201944s |
| 英文摘要 | A detailed study on the direct synthesis of biocompatible polyesters (e.g., PIA, PLGA or PCL) microcapsules and multifunctional microcapsules, which does not require any template and core removal, is presented. The technique is based on the modified self-emulsification process within the emulsion droplets by simply adding sodium dioctyl sulfosuccinate (Aerosol OT or AOT) as a cosurfactant to the initial polymer solution, followed by double emulsion formation due to the coalescence of the internal water droplets. Microcapsules with tunable sizes (ranging from hundreds of nanometers to tens of micrometers) and morphologies were then obtained through solidification of droplet shell of the double emulsion via solvent removal. In this report, we have systematically investigated the effect of experimental parameters, such as polymer and AOT concentration, polymer molecular weight on the double emulsion formation process, and the final morphologies of the microcapsules. We demonstrate that the capsules can encapsulate either hydrophobic or hydrophilic dyes during solvent evaporation. Dye-release studies show a correlation between shell thickness, capsules size, and diffusive release rate, providing insights into the shell formation and shell thickness processing. Moreover, hydrophobic nanoparticles, such as oleic-acid coated Fe(3)O(4) nanoparticles and quantum dots, can also be incorporated into the walls of the microcapsules. Such functional microcapsules might find applications in the fields of controlled release, bioimaging, diagnostics, and targeting. |
| 语种 | 英语 |
| WOS记录号 | WOS:000293662800077 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71811]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhu, Jintao |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Mat Chem & Serv Failure, Wuhan 430074, Peoples R China 2.Huazhong Univ Sci & Technol, Natl Engn Ctr Nanomed, Wuhan 430074, Peoples R China 3.Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Xi,Zhao, Ziliang,Nie, Wei,et al. Biodegradable Polymer Microcapsules Fabrication through a Template-Free Approach[J]. LANGMUIR,2011,27(16):10265-10273. |
| APA | Yu, Xi.,Zhao, Ziliang.,Nie, Wei.,Deng, Renhua.,Liu, Shanqin.,...&Ji, Xiangling.(2011).Biodegradable Polymer Microcapsules Fabrication through a Template-Free Approach.LANGMUIR,27(16),10265-10273. |
| MLA | Yu, Xi,et al."Biodegradable Polymer Microcapsules Fabrication through a Template-Free Approach".LANGMUIR 27.16(2011):10265-10273. |
入库方式： OAI收割
来源：化学研究所
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